Cyanidin-3-O-rhamnoside chloride
Cyanidin-3-O-rhamnoside inhibited cytochromes P450.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Effects of Anthocyanidins and Anthocyanins on the Expression and Catalytic Activities of CYP2A6, CYP2B6, CYP2C9, and CYP3A4 in Primary Human Hepatocytes and Human Liver Microsomes.[Reference:
WebLink]
Anthocyanidins and anthocyanins are pharmacologically active constituents of various berry fruits, such as blueberry and cranberry. These compounds are also contained in massively used nutritional supplements based on extracts or dry matter from berry fruits.
METHODS AND RESULTS:
In the current study, we evaluated the effects of anthocyanidins and anthocyanins of the expression and catalytic activity of major drug-metabolizing enzymes CYP2C9, CYP2A6, CYP2B6 and CYP3A4 in primary cultures of human hepatocytes and human liver microsomes. Expression of mRNA was quantified by qRT-PCR. Expression of proteins was evaluated by western bloting and immunochemiluminiscence. Catalytic activity of CYP enzymes was measured by HPLC using specific enzyme substrates. Tested anthocyanidins (6) and anthocyanins (21) did not induce the expression of mRNA and protein of CYP2C9, CYP2A6, CYP2B6 and CYP3A4 genes in human hepatocytes. Catalytic activities of CYP2C9, CYP2A6, CYP2B6 and CYP3A4 enzymes were inhibited by all anthocyanidins in different extent (e.g. delphinidin inhibits CYP3A4 by >90% at 100 μM with IC50 32μM). Out of 21 anthocyanins tested, only cyanidin-3-O-rhamnoside (Cyanidin-3-O-rhamnoside chloride, CYP3A4 by >75% at 100 μM with IC50 44μM) and two glycosides of delphinidin significantly inhibited examined cytochromes P450.
CONCLUSIONS:
It may be concluded, that in the ranges of common ingestion of either food or a dietary supplement an induction or significant inhibition of CYP2C9, CYP2A6, CYP2B6 and CYP3A4 activity is most probably not expected.
