Coronarin B
Coronarin B has cytotoxic activity, it also has modest antiplasmodial activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Planta Med. 2002 Jul;68(7):642-4.
Antiplasmodial activity of labdanes from Aframomum latifolium and Aframomum sceptrum.[Pubmed:
12143001]
METHODS AND RESULTS:
Bioguided fractionation of extracts of Aframomum latifolium and A. sceptrum (Zingiberaceae) resulted in isolation of (+)-( S)-nerolidol and seven labdanes, Coronarin B, galanal A and B, galanolactone, ( E)-8beta,17-epoxylabd-12-ene-15,16-dial, (+)-( E)-labda-8(17), 12-diene-15,16-dial and its diethyl acetal, the latter being presumably an isolation artefact.
CONCLUSIONS:
The labdanes show a modest in vitro activity against a chloroquine-sensitive Plasmodium falciparum strain.
Phytochemistry,1994,37(5): 1383-1388.
Labdane diterpenes from rhizomes of Hedychium coronarium[Reference:
WebLink]
METHODS AND RESULTS:
Three new labdane diterpenes were isolated together with four known diterpenes [(E)-labda-8(17),12-diene-15,16-dial, Coronarin B and D, and isocoronarin D] from rhizomes of Hedychium coronarium.
CONCLUSIONS:
The structures of the new compounds were determined by spectroscopic evidence to be labda-8(17), 11,13-trien-15(16)-olide, an ester of labda-8(17), 11,13-trien-15-al-16-oic acid and isocoronarin D, and 7β-hydroxyCoronarin B.
Planta Med., 1988, 54(54):311-5.
Cytotoxic Diterpenes from the Rhizomes of Hedychium coronarium[Reference:
WebLink]
METHODS AND RESULTS:
Four new labdane-type diterpenes, Coronarin A, Coronarin B, Coronarin C, and Coronarin D, and one known labdane-type diterpene, (E)-labda-8(17), 12- diene-15, 16-dial were isolated as cytotoxic prinicples from the rhizomes of Hedychium coronarium, Zingiberaceae. The structures were established by chemical and spectroscopic methods.
