Conopharyngine
Standard reference
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Neuropharmacology.1973 Mar;12(3):239-244.
Structure-activity relationships of intracerebrally injected tremorigenic indole alkaloids.[Reference:
WebLink]
METHODS AND RESULTS:
The indole alkaloids harmane, harmine, ibogaine, iboxygaine and ibogaline caused tremor in mice when injected intracerebrally. Harmol, voacangine, voacristine and Conopharyngine were inactive in this respect. Chemical structure strongly influences tremorigenic potency which is increased by a methoxy group and reduced or abolished by a hydroxy or carbomethoxy group.
CONCLUSIONS:
The great importance of chemical structure for tremorigenic power of indole alkaloids points to specific receptors for these drugs in the brain.
Helvetica Chimica Acta.1975; 58(1):211–230.
Über Umwandlungen der Iboga-Alkaloide Voacangin und Conopharyngin 154. Mitteilung über Alkaloide.[Reference:
WebLink]
METHODS AND RESULTS:
The reduction products voacanginol (3) and conopharynginol (4), obtained from the indole alkaloids voacangine (1) and Conopharyngine (2) respectively, gave, by the treatment of their tosylates 5 und 6 with triethylamine, two fragmentation products, voaenamine (7) (70–80%) and conoenamine (8) (25–45%) respectively (Scheme 1).
CONCLUSIONS:
The structures of 7 and 8 were derived from spectroscopic evidence and some chemical transformations.
