Cochinchinenin C
There is a synergistic interaction between loureirin A and Cochinchinenin C, and the fluorescence quenching of HSA by loureirin A (or Cochinchinenin C) is a combined quenching procedure (dynamic and static quenching).
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Eur J Med Chem. 2015 Mar 26;93:492-500.
Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.[Pubmed:
25734332]
METHODS AND RESULTS:
The interactions of loureirin A (LA) and Cochinchinenin C (CC) with human serum albumin (HSA) under simulated physiological conditions (pH = 7.4) have been studied with fluorescence, UV-vis absorption spectroscopic method and molecular docking technique. The results indicated that there was a synergistic interaction between LA and Cochinchinenin C, and the fluorescence quenching of HSA by LA (or Cochinchinenin C) was a combined quenching procedure (dynamic and static quenching). At low compound concentrations, the quenching constants KSV of Cochinchinenin C was larger than that of LA, which meant the Cochinchinenin C efficacy may be better than that of LA. The negative △H and △S values suggested hydrogen bonds and van der Waals forces played the major role in the binding of LA (or Cochinchinenin C) to HSA.
CONCLUSIONS:
The efficiency of energy transfer and distance between the compounds and HSA was calculated. Moreover, the results of synchronous and three-dimensional fluorescence demonstrated that the HSA microenvironment was changed in the presence of LA (or Cochinchinenin C). Finally, the binding of LA (or Cochinchinenin C) to HSA was modeled by molecular docking, which is in good accordance with the experimental studies.
