Chrysosplenetin

Chrysosplenetin
Product Name Chrysosplenetin
CAS No.: 603-56-5
Catalog No.: CFN97026
Molecular Formula: C19H18O8
Molecular Weight: 374.4 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Targets: P450 (e.g. CYP17) | Antifection
Source: The herbs of Laggera pterodonta
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $138/20mg
Chrysosplenetin is a metabolic inhibitor of artemisinin, it has strong activity in vitro against EV71 with low cytotoxicity. Co-administration of artemisinin(ART) with chrysosplenetin(CHR) in ratio of 1:2 achieved a synergic anti-malarial effect partly because of the noncompetitive or uncompetitive inhibition of CHR of drug-metabolism enzymes, especially CYP3A which is closely related to the auto-induction of ART.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J. of Agricultural Science2015, 1916-9760
  • Appl. Sci.2020, 10(8),2804
  • Methods Protoc.2024, 7(6):95.
  • Br J Pharmacol.2016, 173(2):396-410
  • Chin J Appl. Physiol.2019, 35(3):283-288
  • Ind. J. Pharm. Edu. Res.2023; 57(3):1132-1139.
  • Proc Biol Sci.2024, 291:20232298.
  • Nat Prod Communications2018, 10.1177
  • Toxins (Basel).2022, 14(12):824.
  • Front Nutr.2023, 10:1181135.
  • Ganoderic acid G

    Catalog No: CFN90801
    CAS No: 98665-22-6
    Price: $318/20mg
    Isoscoparin-2''-Beta-D-glucopyranoside

    Catalog No: CFN90900
    CAS No: 97605-25-9
    Price: $238/5mg
    Reynosin

    Catalog No: CFN98344
    CAS No: 28254-53-7
    Price: Inquiry(manager@chemfaces.com)
    Saikosaponin D

    Catalog No: CFN99989
    CAS No: 20874-52-6
    Price: $40/20mg
    Soyasaponin Bb

    Catalog No: CFN90456
    CAS No: 51330-27-9
    Price: $138/20mg
    Zhongguo Zhong Yao Za Zhi. 2013 Oct;38(19):3363-7.
    Determination of chrysosplenetin, metabolic inhibitor of artemisinin, in rat plasma by UPLC-ms/MS and study on its pharmacokinetics.[Pubmed: 24422409]

    METHODS AND RESULTS:
    The study aimed to develop the assay of Chrysosplenetin (CHR), a metabolic inhibitor of artemisinin by UPLC-MS/MS in rat plasma and investigate the pharmacokinetics parameters of Chrysosplenetin.The assay was linear in the range 5-5 000 microg L-1 (r =0. 999 3) with recoveries in the range from 69. 0% to 81.2% and satisfied inter-, intra- precision and accuracy. Chrysosplenetin after oral administration is not easy to absorb with double or multimodal peak phenomenon. The t1/2 of Chrysosplenetin after intravenous injection was very short and that of low, medium, and high dosage was (17. 01 +/- 8. 06) , (24. 62 +/- 4. 59), (28. 46+/- 4. 63) min, respectively.
    CONCLUSIONS:
    The developed method was special, rapid, and sensitive for determination of Chrysosplenetin pharmacokinetics.
    Eur J Pharm Sci. 2011 Oct 9;44(3):392-8.
    Inhibition of enterovirus 71 replication by chrysosplenetin and penduletin.[Pubmed: 21914477]
    In recent years, enterovirus 71 (EV71) infections have caused an increasing epidemic in young children, accompanying with more severe nervous system disease and more deaths. Unfortunately, there is no specific medication for it so far.
    METHODS AND RESULTS:
    Here we investigated the anti-EV71 activity of Chrysosplenetin and penduletin, two o-methylated flavonols isolated from the leaves of Laggera pterodonta. These two compounds were found to have strong activity in vitro against EV71 with low cytotoxicity. In the cytopathic effect (CPE) inhibition assays, both plaque reduction assay and virus yield inhibition assay, the compounds showed a similar 50% inhibitory concentration (IC(50)) value of about 0.20 μM.
    CONCLUSIONS:
    The selectivity indices (SI) of Chrysosplenetin and penduletin were 107.5 and 655.6 in African green monkey kidney (Vero) cells, and 69.5 and 200.5 in human rhabdomyosarcoma (RD) cells, accordingly.
    Malaria J., 2015, 14(1):1-13.
    Impact of chrysosplenetin on the pharmacokinetics and anti-malarial efficacy of artemisinin against Plasmodium berghei as well as in vitro CYP450 enzymatic activities in rat liver microsome.[Pubmed: 26537009]
    Artemisinin (ART) is an efficacious and safe anti-malarial drugs but has low oral bioavailability and auto-induction profiles during multiple dosing. The pharmacokinetic disadvantages have been found to partially depend on the induction of cytochrome P-450 enzymes by ART and resulted in the therapeutic failure due to insufficient drug levels.
    METHODS AND RESULTS:
    The present study, therefore, investigated the impacts of Chrysosplenetin (CHR), a polymethoxylated flavonoid from Artemisia annua, on the pharmacokinetics and the anti-malarial efficacy of ART against Plasmodium berghei. The inhibition of CHR on enzymatic activity of CYP1A2, CYP2A, CYP2C19, CYP2D6, CYP2E1, and CYP3A in rat liver microsome was also investigated. IC50, Km, Ki, and inhibitory type of CHR were respectively calculated. Co-administration of ART with CHR in ratio of 1:2 achieved a synergic anti-malarial effect partly because of the noncompetitive or uncompetitive inhibition of CHR of drug-metabolism enzymes, especially CYP3A which is closely related to the auto-induction of ART.
    1,7-Diphenyl-5-hydroxy-4,6-hepten-3-one

    Catalog No: CFN95171
    CAS No: 87095-77-0
    Price: $318/10mg
    (E)-6-O-(p-coumaroyl)scandoside methyl ester

    Catalog No: CFN95192
    CAS No: 83946-90-1
    Price: $218/10mg
    Peucenidin

    Catalog No: CFN95272
    CAS No: 33044-93-8
    Price: $318/5mg
    Diosmin Impurity 5

    Catalog No: CFN95311
    CAS No: 122087-66-5
    Price: $318/10mg
    Jacquilenin

    Catalog No: CFN95434
    CAS No: 7726-34-3
    Price: $318/5mg
    12beta-Acetoxy-3beta-hydroxy-7,11,15,23-tetraoxo-lanost-8,20-diene-26-oic acid

    Catalog No: CFN95468
    CAS No: 1085338-75-5
    Price: $318/5mg
    5-O-Coumaroylquinic acid

    Catalog No: CFN95507
    CAS No: 32451-86-8
    Price: $318/5mg
    12-Acetoxy ganoderic acid D

    Catalog No: CFN95535
    CAS No: N/A
    Price: $318/5mg
    (Z)-Ferulic acid 4-O-beta-D-glucoside

    Catalog No: CFN95546
    CAS No: 94942-20-8
    Price: $318/10mg
    Schisphenlignan I

    Catalog No: CFN95586
    CAS No: 1542234-14-9
    Price: $318/5mg