Ayanin

Ayanin
Product Name Ayanin
CAS No.: 572-32-7
Catalog No.: CFN96157
Molecular Formula: C18H16O7
Molecular Weight: 344.3 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Targets: P450 (e.g. CYP17) | PARP | IL Receptor | TNF-α | IFN-γ | Potassium Channel
Source: The rhizomes of Curcuma aromatica
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $288/10mg
Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma.The IC(50) value of Ayanin (quercetin-3,7,4'-O-trimethylether) is 2.2microM for inhibiting interleukin (IL)-4 production from purified basophils.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Environ Toxicol.2020, doi: 10.1002
  • Molecules.2020, 25(21):5087.
  • Phytochem Anal.2021, 32(6):970-981.
  • Molecules.2018, 23(9):E2121
  • Curr Issues Mol Biol.2023, 45(3):2136-2156.
  • J. Food Composition and Anal.2022, V 109:104482.
  • Life (Basel).2021, 11(12):1399.
  • Plos One.2020, 10.1371
  • Fitoterapia.2022, 105141.
  • LWT2021, 150:112021.
  • Spinacetin

    Catalog No: CFN95194
    CAS No: 3153-83-1
    Price: $318/5mg
    Jaceidin

    Catalog No: CFN99032
    CAS No: 10173-01-0
    Price: Inquiry(manager@chemfaces.com)
    Jaceidin triacetate

    Catalog No: CFN99482
    CAS No: 14397-69-4
    Price: Inquiry(manager@chemfaces.com)
    Chrysosplenetin

    Catalog No: CFN97026
    CAS No: 603-56-5
    Price: $138/20mg
    4',5,7-Trihydroxy 3,3',6,8-tetramethoxyflavone

    Catalog No: CFN70415
    CAS No: 58130-91-9
    Price: Inquiry(manager@chemfaces.com)
    3',4',7,8-Tetramethoxyflavone

    Catalog No: CFN70432
    CAS No: 65548-55-2
    Price: $100/20mg
    4'-hydroxy-6,7,8,3'-tetramethoxyflavonol

    Catalog No: CFN91846
    CAS No: 1879030-01-9
    Price: $318/5mg
    5,7,3',4'-Tetramethoxyflavone

    Catalog No: CFN91116
    CAS No: 855-97-0
    Price: $30/20mg
    Retusin

    Catalog No: CFN89520
    CAS No: 1245-15-4
    Price: $158/10mg
    Quercetin 3,5,7,3,4-pentamethyl ether

    Catalog No: CFN70262
    CAS No: 1247-97-8
    Price: Inquiry(manager@chemfaces.com)
    Biochem Biophys Res Commun. 2012 Nov 9;428(1):116-20.
    Ayanin diacetate-induced cell death is amplified by TRAIL in human leukemia cells.[Pubmed: 23063980]
    Here we demonstrate that the semi-synthetic flavonoid Ayanin diacetate induces cell death selectively in leukemia cells without affecting the proliferation of normal lymphocytes.
    METHODS AND RESULTS:
    Incubation of human leukemia cells with Ayanin diacetate induced G(2)-M phase cell cycle arrest and apoptosis which was prevented by the non-specific caspase inhibitor z-VAD-fmk and reduced by the overexpression of Bcl-x(L). Ayanin diacetate-induced cell death was found to be associated with: (i) loss of inner mitochondrial membrane potential, (ii) the release of cytochrome c, (iii) the activation of multiple caspases, (iv) cleavage of poly(ADP-ribose) polymerase and (v) the up-regulation of death receptors for TRAIL, DR4 and DR5. Moreover, the combined treatment with Ayanin diacetate and TRAIL amplified cell death, compared to single treatments.
    CONCLUSIONS:
    These results provide a basis for further exploring the potential applications of this combination for the treatment of cancer.
    Eur J Pharmacol. 2010 Jun 10;635(1-3):198-203.
    Ayanin, a non-selective phosphodiesterase 1-4 inhibitor, effectively suppresses ovalbumin-induced airway hyperresponsiveness without affecting xylazine/ketamine-induced anesthesia.[Pubmed: 20307524 ]
    In recent in vitro reports, the IC(50) value of Ayanin (quercetin-3,7,4'-O-trimethylether) was 2.2microM for inhibiting interleukin (IL)-4 production from purified basophils, and its therapeutic ratio was >19. Therefore, we were interested in investigating the effects on ovalbumin induced airway hyperresponsiveness in vivo, and to clarify its potential for treating asthma.
    METHODS AND RESULTS:
    Ayanin (30-100micromol/kg, orally (p.o.)) dose-dependently and significantly attenuated the enhanced pause (P(enh)) value induced by methacholine in sensitized and challenged mice. It also significantly suppressed the increases in total inflammatory cells, macrophages, lymphocytes, neutrophils, and eosinophils, and levels of cytokines, including IL-2, IL-4, IL-5, and tumor necrosis factor (TNF)-alpha in bronchoalveolar lavage fluid of these mice. However, at 100micromol/kg, it significantly enhanced the level of interferon (IFN)-gamma. In addition, Ayanin (30-100micromol/kg, p.o.) dose-dependently and significantly suppressed total and OVA-specific immunoglobulin (Ig)E levels in the serum and bronchoalveolar lavage fluid, and enhanced the IgG(2a) level in serum of these mice.
    CONCLUSIONS:
    In the present results, Ayanin did not affect xylazine/ketamine-induced anesthesia, suggesting that Ayanin has few or no adverse effects, such as nausea, vomiting, and gastric hypersecretion. In conclusion, the above results suggest that Ayanin may have the potential for use in treating allergic asthma.
    J Ethnopharmacol. 2004 Sep;94(1):185-9.
    Vasorelaxant effect of new neo-clerodane diterpenoids isolated from Croton schiedeanus.[Pubmed: 15261981 ]

    METHODS AND RESULTS:
    The vasorelaxant effect of two new neo-clerodane diterpenoids, (12R)-12-hydroxycascarillone and 5beta-hydroxy-cis-dehydrocrotonin, in addition to the known cis-dehydrocrotonin and trans-dehydrocrotonin, all them previously isolated by us from Croton schiedeanus Schlecht, was studied in isolated aorta rings contracted by high K+ (80 mM) or phenylephrine (1 microM). According to their IC50 values to KCl induced contraction, the potency order was (12R)-12-hydroxycascarillone > cis-dehydrocrotonin > 5beta-hydroxy-cis-dehydrocrotonin > trans-dehydrocrotonin (0.3, 1.5, 96 and >100 mM, respectively). The possible cooperativity between diterpenoid compounds and the predominant flavonoid (Ayanin) was studied. The vasorelaxant activity of cis-dehydrocrotonin and Ayanin was increased when both compounds were incorporated simultaneously to the aortic rings precontracted with phenylephrine.
    CONCLUSIONS:
    These results suggest that Croton schiedeanus induces its effects via the synergistic actions of several vasodilator substances, among which neo-clerodane diterpenoids play an important role.
    Cistantubuloside C1

    Catalog No: CFN95121
    CAS No: 620632-36-2
    Price: $298/10mg
    Ampelopsin G

    Catalog No: CFN95148
    CAS No: 151487-09-1
    Price: $318/5mg
    Quercetin-3'-glucoside

    Catalog No: CFN95271
    CAS No: 19254-30-9
    Price: $318/10mg
    Perlolyrine

    Catalog No: CFN95291
    CAS No: 29700-20-7
    Price: $413/5mg
    New compound 12 (Rhoifolin analog)

    Catalog No: CFN95371
    CAS No: N/A
    Price: $318/5mg
    10-O-trans-p-coumaroylscandoside

    Catalog No: CFN95391
    CAS No: 870785-25-4
    Price: $318/10mg
    (2S)-5,7,3',4'-tetramethoxyflavanone

    Catalog No: CFN95406
    CAS No: 74628-43-6
    Price: $318/10mg
    Naringenin 7-O-gentiobioside

    Catalog No: CFN95435
    CAS No: 104154-33-8
    Price: $368/5mg
    Pinocembroside

    Catalog No: CFN95444
    CAS No: 75829-43-5
    Price: $118/20mg
    Methyl lucidenate E2

    Catalog No: CFN95569
    CAS No: 98665-12-4
    Price: $413/5mg