Averantin
Averantin exhibits antifungal activity against Fusariumsolani, pathogenic fungus of P. notoginseng, with minimum inhibitory concentrations (MICs) of 16-32 ug/mL, and shows antibacterial activity against Bacillussubtilis with MICs of 16-32 ug/mL.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Pharmacol Rep.2017, 69(6):1224-1231
Journal of Third Military Medical University2019, 41(2):110-115
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J. Mater. Life Sci.2024, 3:2:78-87
Int J Mol Sci.2023, 24(20):15320.
PLoS One.2021, 16(9):e0257243.
ACS Omega.2023, 8(36):32424-32431.
Proc Biol Sci.2024, 291:20232298.
Applied Biological Chemistry2023, 66:8
Preprints2022, 202211.0388.v1.
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Nat Prod Res. 2014;28(24):2334-7.
The antifungal metabolites obtained from the rhizospheric Aspergillus sp. YIM PH30001 against pathogenic fungi of Panax notoginseng.[Pubmed:
25022791 ]
METHODS AND RESULTS:
Eight anthraquinones (1-8), three xanthones (11-13) and two phenols (9-10) were isolated from Aspergillus sp. associated with Panax notoginseng, and their structures were determined as ziganein-1-methyl ether (1), 8-O-methylchrysophanol (2), averythrin (3), averufin (4), 8-O-methyl averufin (5), versicolorin B (6), Averantin (7), methyl-Averantin (8), arugosin C (9), diorcinol (10), sterigmatocystin (11), demethylsterigmatocystin (12) and dihydrosterigmatocystin (13) by spectroscopic analyses. Compounds 1, 2 and 5 were the novel isolates from genus Aspergillus. Compounds 3, 6 and 7 exhibited antifungal activity against Fusariumsolani, pathogenic fungus of P. notoginseng, with minimum inhibitory concentrations (MICs) of 16-32 μg/mL, and compounds 1, 3, 4, 7 and 9 showed antibacterial activity against Bacillussubtilis with MICs of 64-128 μg/mL, 16-32 μg/mL, 8-16 μg/mL, 16-32 μg/mL and 64-128 μg/mL, respectively.
CONCLUSIONS:
The metabolites showed the potential value in the research of antifungal agents, especially in searching for a biocontrol of diseases of P. notoginseng. The preliminary structure-activity relationships have been discussed for some of the compounds.
