Atroscine

Atroscine
Product Name Atroscine
CAS No.: 138-12-5
Catalog No.: CFN00227
Molecular Formula: C17H21NO4
Molecular Weight: 303.36 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Targets: Adrenergic Receptor
Source: The herbs of Atropa belladonna L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Atroscine has adrenolytic activity by its ability to antagonize the lethal effect of epinephrine in rats.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Planta Med.2019, 85(4):347-355
  • Korean Journal of Pharmacognosy2019, 50(4):285-290
  • Separations2023, 10(2), 131.
  • Phytomedicine.2022, 100:154058.
  • Biosci. Rep.2020, 10.1024
  • Food Chem.2019, 278:683-691
  • Ind Crops Prod.2014, 62:173-178
  • Front Neurosci.2019, 13:1091
  • Phytomedicine2022, 104:154318
  • Current Enzyme Inhibition2023, 19(1):55-64(10)
  • Benzoyltropein

    Catalog No: CFN00212
    CAS No: 19145-60-9
    Price: Inquiry(manager@chemfaces.com)
    Cochlearine

    Catalog No: CFN00213
    CAS No: 52418-07-2
    Price: Inquiry(manager@chemfaces.com)
    Tropanyl 3-hydroxy-4-methoxycinnamate

    Catalog No: CFN00216
    CAS No: 86702-58-1
    Price: Inquiry(manager@chemfaces.com)
    Tropacocaine

    Catalog No: CFN00219
    CAS No: 537-26-8
    Price: Inquiry(manager@chemfaces.com)
    Atroscine

    Catalog No: CFN00227
    CAS No: 138-12-5
    Price: Inquiry(manager@chemfaces.com)
    Scopoline

    Catalog No: CFN00228
    CAS No: 487-27-4
    Price: Inquiry(manager@chemfaces.com)
    Tigloyltropeine

    Catalog No: CFN00230
    CAS No: 495-83-0
    Price: Inquiry(manager@chemfaces.com)
    Tigloidine

    Catalog No: CFN00231
    CAS No: 533-08-4
    Price: Inquiry(manager@chemfaces.com)
    Hyoscyamine

    Catalog No: CFN00232
    CAS No: 101-31-5
    Price: $40/20mg
    Hyoscyamine sulfate hydrate

    Catalog No: CFN90713
    CAS No: 620-61-1
    Price: $30/20mg
    Journal of Pharmaceutical Sciences,1966,55(3):280-284.
    Adrenolytic activity of atropine, (+)-hyoscyamine, atroscine, homatropine, and related compounds[Reference: WebLink]

    METHODS AND RESULTS:
    The adrenolytic activity of atropine, ( + ) and (−) hyoscyamine, (−)-hyoscine, Atroscine, and related compounds was determined by their ability to antagonize the lethal effect of epinephrine in rats. (+)-Hyoscyamine was found to be more active than atropine, and atropine was slightly more active than Atroscine (racemic hyos-cine). The levo-isomers, ( − )-hyoscyamine and (−)-hyoscine, were inactive. These results indicate that (+)-hyoscyamine and (+)-hyoscine are responsible for the effect of atropine and Atroscine, respectively.
    CONCLUSIONS:
    Hornatropine and benztropine, but not tropine itself, were active. Benztropine was approximately one-fiftieth as active as phentolamine. A pair of esters of tropine had weak adrenoiytic activity, but their pseudotropine isomers were inactive. Atropine aminoxide (genatropin) and atropine methyl nitrate had no adrenolytic activity.
    Eur J Pharmacol. 1983 May 20;90(1):75-83.
    Structure-activity requirements for hypotension and alpha-adrenergic receptor blockade by analogues of atropine.[Pubmed: 6135619 ]
    The hypotensive action of various antimuscarinic compounds structurally related to atropine was studied in conscious, unanesthetized rats.
    METHODS AND RESULTS:
    The alpha-adrenolytic activity of these agents was assessed both in vivo (blockade of norepinephrine-induced pressor response) and in vitro (displacement of [3H]WB-4101 binding). Benztropine, homatropine and hyoscyamine caused hypotension and produced alpha-adrenergic receptor blockade similar to atropine. Other analogues were either inactive (Atroscine, scopolamine, tropic acid and tropine) or evoked nonspecific changes in blood pressure and lacked alpha-adrenolytic activity (benactyzine, eucatropine, methylatropine, methylhomatropine and methylscopolamine).
    CONCLUSIONS:
    Based on these data, we propose the following structure-activity relationship for hypotension and alpha-adrenolytic activity: (a) the tropine moiety is inactive unless it is attached to another group by an ester linkage, (b) chemical modification of the tropine moiety, including quaternization, decreases potency, (c) the d-stereoisomer appears to be more potent than the corresponding 1-form.
    1,3,6-Tri-O-galloylglucose

    Catalog No: CFN95043
    CAS No: 18483-17-5
    Price: $318/10mg
    3'-Methoxymirificin

    Catalog No: CFN95112
    CAS No: 1297609-29-0
    Price: $318/5mg
    Complanatoside C

    Catalog No: CFN95144
    CAS No: N/A
    Price: $318/5mg
    Puerol B

    Catalog No: CFN95155
    CAS No: 112343-17-6
    Price: $398/5mg
    Pterodonoic acid

    Catalog No: CFN95183
    CAS No: 62458-42-8
    Price: $413/5mg
    15-Methoxy-16-oxo-15,16H-strictic acid

    Catalog No: CFN95261
    CAS No: 1356388-38-9
    Price: $368/5mg
    Naringin 6''-acetate

    Catalog No: CFN95418
    CAS No: 139934-60-4
    Price: $318/5mg
    Gardoside methyl ester

    Catalog No: CFN95467
    CAS No: 93930-20-2
    Price: $318/10mg
    8-epi-Confertin

    Catalog No: CFN95509
    CAS No: 110115-60-1
    Price: $318/5mg
    Ganoderic acid GS-3

    Catalog No: CFN95518
    CAS No: 1206781-66-9
    Price: $413/5mg