Angoline

Angoline
Product Name Angoline
CAS No.: 21080-31-9
Catalog No.: CFN91469
Molecular Formula: C22H21NO5
Molecular Weight: 379.4 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Hylomecon hylomeconoides.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation IC50 & Target;IC50: 11.56 μM (IL6/STAT3 signaling pathway), 3.32 μM (MDA-MB-231), 4.72 μM (H4), 3.14 μM (HepG2)
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Drug Invention Today2019, 12(6):1303-1306
  • Mol Neurobiol.2021, 58(8):3665-3676.
  • J Breast Cancer.2015, 18(2):112-118
  • Int Immunopharmacol.2019, 71:361-371
  • Chem Biodivers.2023, 20(10):e202300741.
  • Pharmacogn J.2022, 14(2):350-357
  • Biomed Pharmacother.2024, 175:116770.
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • Chem Biodivers.2023, 20(12):e202301461.
  • Anal Chim Acta.2021, 1180:338874.
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