7-O-Methyleriodictyol
7-O-Methyleriodictyol inhibits the maximum contractions induced by acetylcholine or oxytocin.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Planta Med. 1993 Feb;59(1):42-5.
Isolation and biological effects of 7-O-methyleriodictyol, a flavanone isolated from Artemisia monosperma, on rat isolated smooth muscles.[Pubmed:
8441781]
METHODS AND RESULTS:
The isolation for the first time from the genus Artemisia (Compositae) of the known flavanone, 7-O-Methyleriodictyol (7-methoxy-5,3',4'-trihydroxy-flavanone), its identification, and its biological effects on rat isolated smooth muscles are described. 7-O-Methyleriodictyol (10(-7) M to 3 x 10(-4) M) caused concentration-dependent inhibition of the amplitude of the phasic contractions and reduced the tone of the ileum, the uterus, and the urinary bladder. It also caused relaxation of the phenylephrine-precontracted pulmonary artery and the acetylcholine-precontracted trachea. The flavanone also shifted to the right the acetylcholine concentration-effect curve on the ileum and the oxytocin concentration-effect curve on the uterus. The maximum contractions induced by acetylcholine or oxytocin were also inhibited by 7-O-Methyleriodictyol.
CONCLUSIONS:
These antispasmodic effects are partly consistent with the use of A. monosperma in folk medicine for certain gastrointestinal disorders.
