6-Hydroxysugiol
6-Hydroxysugiol inhibits proliferation and migration of HepG2 cells and exhibits potent anti-angiogenic activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Latin American Journal of Pharmacy, 2012 , 31 (10) :1457-1463.
6-Hydroxysugiol Isolated from Salvia yunnanensis Inhibits Proliferation and Migration of HepG2 Cells as well as Exhibits Potent Anti-Angiogenic Activity[Reference:
WebLink]
The aim of our study was to investigate the anti-angiogenic effect and anti-tumor activity of 6-Hydroxysugiol isolated from Salvia yunnanensis.
METHODS AND RESULTS:
The cell proliferation was evaluated by MTT assay. The apoptosis of HepG2 was studied through the fluorescence microscope. Anti-angiogenic activity of 6-Hydroxysugiol was tested by chicken chorioallantoic membrane (CAM) model in vivo. In order to study the mechanism of 6-Hydroxysugiol inhibiting angiogenesis, the expression of VEGF in the HepG2 cell and the cell culture fluid were determined by immunocytochemistry and ELISA assay. The results showed that the cell proliferation was inhibited to 76.2% by 6-Hydroxysugiol, at the concentration 0.32 mmol/L. The ability of cells to migrate was significantly reduced by 6-Hydroxysugiol and the 59.72% cells showed the typically apoptotic chromatin fragmentation that were treated with 6-Hydroxysugiol at 0.64 mmol/L. The ex- pression of VEGF in the HepG2 cell and in the cell culture medium were all decreased to by 6-Hydroxysugiol.
CONCLUSIONS:
6-Hydroxysugiol is able to suppress angiogenesis on CAM models. These results suggest that it is de- served further investigation as a promising anti-tumor angiogenesis compound.
Synthesis , 2010 (13) :2223-2232.
Connecting C19 Norditerpenoids to C20 Diterpenes: Total Syntheses of 6Hydroxy5,6-dehydrosugiol, 6-Hydroxysugiol, and Taiwaniaquinone H, and Formal Synthesis of Dichroanone[Reference:
WebLink]
METHODS AND RESULTS:
Oxidation of the B-ring of abietane derivatives by Sharpless- dihydroxylation gave the natural products 6-hydroxy-5,6-dehydrosugiol and 6-Hydroxysugiol. Moreover, further oxidation gave a hydroxy dione derivative that provides a synthetic entry into the C19 taiwaniaquinoid family of natural products.
CONCLUSIONS:
This route is based on biosynthetic considerations and involves a benzilic acid rearrangement followed by decarboxylation. On the basis of this approach, a total synthesis of (-)-taiwaniaquinone H and a formal synthesis of (-)-dichroanone have been achieved.
