6-Hydroxykaempferol
6-Hydroxykaempferol is a competitive inhibitor of tyrosinase compared to L-DOPA, it shows also high antioxidant activities.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Molecules, 2007, 12(1):86-97.
Inhibitory effects of 5,6,7-trihydroxyflavones on tyrosinase.[Pubmed:
17693955]
METHODS AND RESULTS:
Baicalein (1), 6-Hydroxyapigenin (6), 6-hydroxygalangin (13) and 6-hydroxy-kaempferol (14), which are naturally occurring flavonoids from a set of 14 hydroxy-flavones tested, exhibited high inhibitory effects on tyrosinase with respect to L-DOPA, while each of the 5,6,7-trihydroxyflavones 1, 6, 13 or 14 acted as a cofactor to monophenolase. Moreover, 6-Hydroxykaempferol (14) showed the highest activity and was a competitive inhibitor of tyrosinase compared to L-DOPA. 5,6,7-Trihydroxyflavones 1, 6, 13 or 14 showed also high antioxidant activities.
CONCLUSIONS:
Hence, we conclude that the 5,6,7-trihydroxy-flavones are useful as good depigmentation agents with inhibitory effects in addition to their antioxidant properties.
Phytochemistry.1992;31(11):4001–4004.
6-hydroxykaempferol and its glycosides from Carthamus tinctorius petals.[Reference:
WebLink]
METHODS AND RESULTS:
From the dried petals of Carthamus tinctorius, five flavonoids, 6-Hydroxykaempferol, 6-Hydroxykaempferol 3-glucoside, 6-Hydroxykaempferol 3,6-diglucoside, 6-Hydroxykaempferol 3,6,7-triglucoside and 6-Hydroxykaempferol 3-rutinoside-6-glucoside, were isolated along with 13 known compounds, and their structures determined by spectroscopic means including 2D NMR.
