6,7-Dihydroneridienone A
6,7-Dihydroneridienone A exhibits notable leishmanicidal activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Planta Med 2012; 78 - PI239.
Compounds with antileishmanial activity isolated from the stems of Pentalinon andrieuxii.[Reference:
WebLink]
METHODS AND RESULTS:
Bioassay-guided fractionation was conducted on a chloroform-soluble extract of the stems of Pentalinon andrieuxii, a Mayan traditional antileishmanial plant collected in a rainforest region of Mexico, using a Leishmania (L.) mexicana strain of parasites. This led to the isolation of five C21 sterol derivatives, neridienone A (1), 6,7-Dihydroneridienone A (2), cybisterol (3), 12β-hydroxypregn-4-ene-3,20-dione (4), and pentalinonoside (5), two coumarins, fraxidin (6) and fraxetol (7), as well as betulinic acid (8) and (+)-pinoresinol (9).
CONCLUSIONS:
All the isolates were evaluated in vitro for their ability to inhibit the growth of promastigotes of L. mexicana. Compounds 1-4, and 6 were found to exhibit notable leishmanicidal activity in this assay.
