4'-Demethylpodophyllotoxin

4'-Demethylpodophyllotoxin
Product Name 4'-Demethylpodophyllotoxin
CAS No.: 40505-27-9
Catalog No.: CFN90483
Molecular Formula: C21H20O8
Molecular Weight: 400.37 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The herbs of Dysosma pleiantha (Hance) Woodson.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $40/20mg
4'-Demethylpodophyllotoxin exhibits the remarkable cytotoxic potential in diverse cancer cell lines.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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  • The Japan Society for Analytical Chemistry2018, 67(4):201-206
  • Microchemical Journal2023, 194:109249
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  • Front Chem.2024, 12:1385844.
  • Phytother Res.2019, 33(7):1784-1793
  • Comp. & Mathematical Methods in Med.2022, 5475559.
  • ARPN Journal of Eng.& Applied Sci.2016, 2199-2204
  • Int J Mol Sci.2018, 19(9):E2681
  • Immunopharmacol Immunotoxicol.2024, 46(4):496-508.
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    Chem Biol Interact. 2014 Oct 18;224C:100-107.
    4'-Demethyl-deoxypodophyllotoxin glucoside isolated from Podophyllum hexandrum exhibits potential anticancer activities by altering Chk-2 signaling pathway in MCF-7 breast cancer cells.[Pubmed: 25446499]
    We investigated the root of Podophyllum hexandrum as a potential source of lead bioactive metabolites with anticancer activity.
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    The present study led to the isolation of six known aryltetralin-type lignans designated as 4'-demethyl-deoxypodophyllotoxin (1), podophyllotoxin (2), 4'-Demethylpodophyllotoxin (3), podophyllotoxin-4-O-β-d-glucopyranoside (4), 4'-demethyl-deoxypodophyllotoxin-4-O-β-d-glucopyranoside (5), 4'-demethyl-podophyllotoxin-4-O-β-d-glucopyranoside (6), along with three known flavones Kaempferol (7), Quercetin (8), Astragalin (9) from the root of P. hexandrum. Compounds (1-9) exhibited the remarkable cytotoxic potential in diverse cancer cell lines.
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