3beta-Methoxy-2,3-dihydrowithaferin A | CAS:73365-94-3

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Processes2021, 9(1), 153;

Heliyon.2023, e12684.

Nutrients.2022, 14(23):4997.

Molecules.2019, 24(21):E3834

Biomolecules.2019, 9(11):E696

J Ethnopharmacol.2023, 321:117501.

Applied Biological Chemistry2022, 65(77).

FEMS Microbiol Lett.2017, 364(11)

US20170000760 A12016, 42740

Agriculture2022, 12(12), 2173.

J Nat Prod. 2017 Oct 27;80(10):2756-2760.

2,3-Dihydro-3β-methoxy Withaferin-A Protects Normal Cells against Stress: Molecular Evidence of Its Potent Cytoprotective Activity.[Pubmed: 29043807 ]

2,3-Dihydro-3β-methoxy withaferin-A (3beta-Methoxy-2,3-dihydrowithaferin A, 3βmWi-A) is a natural withanolide that is structurally close to withaferin-A (Wi-A), is cytotoxic to human cancer cells, and is a candidate anticancer natural compound.
METHODS AND RESULTS:
Using cell-based biochemical, molecular, and imaging assays, we report that Wi-A and 3βmWi-A possess contrasting activities. Whereas Wi-A caused oxidative stress to normal cells, 3βmWi-A was well tolerated at even 10-fold higher concentrations. Furthermore, it promoted survival and protected normal cells against oxidative, UV radiation, and chemical stresses. We provide molecular evidence that 3βmWi-A induces antistress and pro-survival signaling through activation of the pAkt/MAPK pathway.
CONCLUSIONS:
We demonstrate that 3βmWi-A (i) contrary to Wi-A is safe and possesses stress-relieving activity, (ii) when given subsequent to a variety of stress factors including Wi-A, protects normal cells against their toxicity, and (iii) is a vital compound that may guard normal cells against the toxicity associated with various targeted therapeutic regimes in clinical practice.

Product Name	3beta-Methoxy-2,3-dihydrowithaferin A
CAS No.:	73365-94-3
Catalog No.:	CFN91105
Molecular Formula:	C₂₉H₄₂O₇
Molecular Weight:	502.65 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Targets:	Akt \| MAPK
Source:	The herbs of Ashwagandha ayurvedic
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:	$338/10mg