2-Hydroxytetracosanoic acid ethyl ester | CAS:124111-47-3

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Antimalarial Activity of Axidjiferosides, New β-Galactosylceramides from the African Sponge Axinyssa djiferi.[Reference: WebLink]

METHODS AND RESULTS:
The marine sponge, Axinyssa djiferi, collected on mangrove tree roots in Senegal, was investigated for glycolipids. A mixture containing new glycosphingolipids, named axidjiferoside-A, -B and -C, accounted for 0.07% of sponge biomass (dry weight) and for 2.16% of total lipids. It showed a significant antimalarial activity, with a 50% inhibitory concentration (IC50) of 0.53 ± 0.2 μM against a chloroquine-resistant strain of Plasmodium falciparum. They were identified as homologous β-galactopyranosylceramides composed of 2-amino-(6E)-octadec-6-en-1,3,4-triol, and the major one, axidjiferoside-A (around 60%), contained 2-hydroxytetracosanoic acid(2-Hydroxytetracosanoic acid ethyl ester). Cytotoxicity was studied in vitro on human cancer cell lines (multiple myeloma, colorectal adenocarcinoma, glioblastoma and two lung cancer NSCLC-N6 and A549). Results of this investigation showed that axidjiferosides are of interest, because they proved a good antiplasmodial activity, with only a low cytotoxicity against various human cell lines and no significant antitrypanosomal and antileishmanial activity.
CONCLUSIONS:
Thus, it seems that galactosylceramides with a β anomeric configuration may be suitable in searching for new antimalarial drugs.

Product Name	2-Hydroxytetracosanoic acid ethyl ester
CAS No.:	124111-47-3
Catalog No.:	CFN99353
Molecular Formula:	C₂₆H₅₂O₃
Molecular Weight:	412.7 g/mol
Purity:	>=98%
Type of Compound:	Lipids
Physical Desc.:	Powder
Source:	The herbs of Adhatoda vasica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: