2,4-Dihydroxybenzoic acid

2,4-Dihydroxybenzoic acid
Product Name 2,4-Dihydroxybenzoic acid
CAS No.: 89-86-1
Catalog No.: CFN70215
Molecular Formula: C7H6O4
Molecular Weight: 154.1 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Targets: α-glucosidase enzyme
Source: The stems of Malaysian U. Cordata Var. Ferruginea
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $30/20mg
2,4-Dihydroxybenzoic acid is found frequently as a pollutant in natural waters and represents a threat to water quality because it is a precursor to the formation of quinones which are highly toxic. It could as a novel eluent in single column anion chromatography. 2,4-Dihydroxybenzoic acid shows strong inhibitory effects against α-glucosidase enzyme with IC50 values of 549 μg/mL .
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Chemical Engineering Science, 2002, 57(5):767-778.
    Anodic oxidation of 2,4-dihydroxybenzoic acid for wastewater treatment: Study of ultrasound activation[Reference: WebLink]

    METHODS AND RESULTS:
    The electrooxidation at a platinum electrode of 2,4-Dihydroxybenzoic acid (2,4-DHBA) assisted by ultrasound was investigated at two frequencies (20 and ). At high frequency, hydroxyl radicals are generated, which directly oxidise organic pollutants whereas, at low frequency, mass transfer rates of the electroactive species from the bulk solution to the electrode surface as well as adsorption/desorption mechanisms are considerably accelerated. For a initial concentration and a current density, the TOC decrease was 47% after passing an electricity amount of at low frequency and only 32% after passing at high-frequency sonoelectrooxidation or electrooxidation. At low frequency, 2,4-DHBA degradation is accelerated and final TOC is lower: cavitation phenomena ensure the cleaning of the electrode surface thus increasing the active electrode surface.
    CONCLUSIONS:
    Observed by-products of sonoelectrodegradation are the same as for electrooxidation alone, including the following: 2,3,4- and 2,4,5-trihydroxybenzoic acids (THBA), maleic acid, glyoxylic acid and oxalic acid. Fewer intermediate aromatic compounds are formed at low-frequency irradiation. Moreover, the faradaic yield increases under low-frequency sonication, showing a more efficient use of electrochemical energy. Nevertheless, the overall energy consumption remains high .
    Journal of Chromatography A, 1986, 367(1):69-76.
    2,4-Dihydroxybenzoic acid as a novel eluent in single column anion chromatography[Reference: WebLink]
    2,4-Dihydroxybenzoic acid has been studied as an eluent for single column ion chromatography with indirect UV detection. The advantages of this eluent are discussed.
    METHODS AND RESULTS:
    Only low concentrations of 2,4-Dihydroxybenzoic acid in the mobile phase are needed. Eighteen anions could be detected. The early eluting anions such as silicate and fluoride show well separated peaks and can be determined simultaneously with other common anions. The detection limit is e.g., 150 ppb for silicate (as Si) and 50 ppb for fluoride. It is shown that this method can be applied to the determination of anions in tap- and mineral-water samples. A baseline separation is obtained in about 20 min. Many other applications are possible because of the high resolution of this system, thus also silicate, phosphate and arsenate can be separated.
    CONCLUSIONS:
    The loss of ion-exchange capacity poses no problem since a decrease in the concentration of 2,4-Dihydroxybenzoic acid results in almost the same chromatogram as before.
    Journal of Hazardous Materials, 2012, 237-238(OCT.30):p.71-78.
    Degradation of 2,4-dihydroxibenzoic Acid by Vacuum UV Process in Aqueous Solution: Kinetic, Identification of Intermediates and Reaction Pathway。[Reference: WebLink]
    2,4-Dihydroxybenzoic acid (2,4-DHBA) is found frequently as a pollutant in natural waters and represents a threat to water quality because it is a precursor to the formation of quinones which are highly toxic.
    METHODS AND RESULTS:
    The degradation of 2,4-DHBA using the vacuum UV photolysis of water has been investigated. Irradiation was carried out in an annular photoreactor equipped with a Xe-excimer lamp situated in the centre and emitting at 172 nm. The degradation kinetic followed a pseudo first order and the reaction has been found to be very heterogeneous, especially at low concentration. Impacts of oxygen or temperature have also been investigated but no effect has been shown. LC-MS and HPLC-UV combined with other analytical techniques allowed the identification of the formation of trihydroxybenzoïc acids and trihydroxybenzenes which underwent a ring opening, conducting to the formation of aliphatic products named α, β, δ and γ. These products were in turn degraded successively into maleïc acid, malic and succinic acid, malonic acid, glyoxalic acid and oxalic acid before reaching the complete mineralization in about 180 min. The proposed reaction pathway has shown to be very different from the one observed for the TiO(2) photocatalysis which involves only holes (h(+)) without any formation of aromatic intermediates.
    CONCLUSIONS:
    The different behaviours of 2,4-DHBA towards the h(+) and HO make it a good probe to identify involved entities.
    Molecules, 2016, 21(525):1-11.
    Chemical Constituents of Malaysian U. Cordata Var. Ferruginea and Their in Vitro α-Glucosidase Inhibitory Activities[Reference: WebLink]
    Continuing our interest in the Uncaria genus, the phytochemistry and the in-vitro α-glucosidase inhibitory activities of Malaysian Uncaria cordata var. ferruginea were investigated.
    METHODS AND RESULTS:
    The phytochemical study of this plant, which employed various chromatographic techniques including recycling preparative HPLC, led to the isolation of ten compounds with diverse structures comprising three phenolic acids, two coumarins, three flavonoids, a terpene and an iridoid glycoside. These constituents were identified as 2-hydroxybenzoic acid or salicylic acid (1), 2,4-Dihydroxybenzoic acid (2), 3,4-dihydroxybenzoic acid (3), scopoletin or 7-hydroxy-6-methoxy-coumarin (4), 3,4-dihydroxy-7-methoxycoumarin (5), quercetin (6), kaempferol (7), taxifolin (8), loganin (9) and β-sitosterol (10). Structure elucidation of the compounds was accomplished with the aid of 1D and 2D Nuclear Magnetic Resonance (NMR) spectral data and Ultraviolet-Visible (UV-Vis), Fourier Transform Infrared (FTIR) spectroscopy and mass spectrometry (MS). In the α-glucosidase inhibitory assay, the crude methanolic extract of the stems of the plant and its acetone fraction exhibited strong α-glucosidase inhibition activity of 87.7% and 89.2%, respectively, while its DCM fraction exhibited only moderate inhibition (75.3%) at a concentration of 1 mg/mL. The IC50 values of both fractions were found to be significantly lower than the standard acarbose suggesting the presence of potential α-glucosidase inhibitors. Selected compounds isolated from the active fractions were then subjected to α-glucosidase assay in which 2,4-Dihydroxybenzoic acid and quercetin showed strong inhibitory effects against the enzyme with IC50 values of 549 and 556 μg/mL compared to acarbose (IC50 580 μg/mL) while loganin and scopoletin only showed weak α-glucosidase inhibition of 44.9% and 34.5%, respectively.
    CONCLUSIONS:
    This is the first report of the isolation of 2-hydroxybenzoic acid, 2,4-Dihydroxybenzoic acid and loganin from the genus and the first report of the α-glucosidase inhibitory potential of 2,4-Dihydroxybenzoic acid.
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