2,2-Dimethyl-6-phenylpyrano[3,4-b]pyran-8-one
2,2-Dimethyl-6-phenylpyrano[3,4-b]pyran-8-one is a natural product from the metabolites of Hypericum revolutum ssp.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Phytochemistry. 2009 Feb;70(3):403-6.
Dibenzofuran and pyranone metabolites from Hypericum revolutum ssp. revolutum and Hypericum choisianum.[Pubmed:
19200564 ]
METHODS AND RESULTS:
In a project to isolate and characterise anti-staphylococcal compounds from members of the genus Hypericum, a dibenzofuran and a pyranone were isolated from the dichloromethane and hexane extracts of Hypericum revolutum ssp. revolutum Vahl (Guttiferae) and Hypericum choisianum Wall. ex. N. Robson (Guttiferae), respectively. The structures of these compounds were elucidated by 1- and 2D-NMR spectroscopy and mass spectrometry as 3-hydroxy-1,4,7-trimethoxydibenzofuran (1) and 4-(3-O-3'')-3''-methylbutenyl-6-phenyl-pyran-2-one (2,2-Dimethyl-6-phenylpyrano[3,4-b]pyran-8-one,2). The metabolites were evaluated against a panel of multidrug-resistant strains of Staphylococcus aureus.
CONCLUSIONS:
Compound 1 exhibited a minimum inhibitory concentration (MIC) of 256 microg/ml, whereas compound 2 was inactive at a concentration of 512 microg/ml.
![2,2-Dimethyl-6-phenylpyrano[3,4-b]pyran-8-one](https://www.chemfaces.com/structural/2-2-Dimethyl-6-phenylpyrano-3-4-b-pyran-8-one-CFN96978.jpg "2,2-Dimethyl-6-phenylpyrano[3,4-b]pyran-8-one")
