12-Oxocalanolide A

12-Oxocalanolide A
Product Name 12-Oxocalanolide A
CAS No.: 161753-49-7
Catalog No.: CFN97812
Molecular Formula: C22H24O5
Molecular Weight: 368.43 g/mol
Purity: >=98%
Type of Compound: Coumarins
Physical Desc.: Yellow powder
Targets: HIV
Source: The herbs of Calophyllum polyanthum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
12-Oxocalanolide A is an inhibitor of HIV-1 reverse transcriptase (RT) and exhibits activity against a variety of viruse selected for resistance to other HIV-1 nonnucleoside RT inhibitors.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • bioRxiv - Biochemistry2023, 548213.
  • Phytochemistry Letters2015, 243-247
  • Industrial Crops and Products2022, 188:115596.
  • Int Immunopharmacol.2019, 71:22-31
  • Chem Biol Interact.2018, 290:44-51
  • Int J Nanomedicine.2024, 19:1683-1697.
  • University of Guelph2021, 12.
  • Nat Prod Sci.2016, 22(2)
  • Food and Fermentation Industries2019, 45(7):45-51
  • Biochem Biophys Res Commun.2018, 505(4):1148-1153
  • 7-Hydroxy-3-prenylcoumarin

    Catalog No: CFN97429
    CAS No: 86654-26-4
    Price: Inquiry(manager@chemfaces.com)
    7-Hydroxy-6-methoxy-3-prenylcoumarin

    Catalog No: CFN98374
    CAS No: 299159-90-3
    Price: Inquiry(manager@chemfaces.com)
    3-(1,1-Dimethylallyl)-8-hydroxy-7-methoxycoumarin

    Catalog No: CFN89287
    CAS No: 61899-42-1
    Price: Inquiry(manager@chemfaces.com)
    Chalepensin

    Catalog No: CFN89033
    CAS No: 13164-03-9
    Price: Inquiry(manager@chemfaces.com)
    Rutamarin

    Catalog No: CFN89223
    CAS No: 14882-94-1
    Price: Inquiry(manager@chemfaces.com)
    Evodosin A

    Catalog No: CFN89021
    CAS No: 1291053-38-7
    Price: Inquiry(manager@chemfaces.com)
    12-Oxocalanolide A

    Catalog No: CFN97812
    CAS No: 161753-49-7
    Price: Inquiry(manager@chemfaces.com)
    Calanolide E

    Catalog No: CFN99466
    CAS No: 142566-61-8
    Price: Inquiry(manager@chemfaces.com)
    7-Amino-4-methylcoumarin

    Catalog No: CFN90420
    CAS No: 106562-32-7
    Price: Inquiry(manager@chemfaces.com)
    Bioorg Med Chem Lett. 1998 Aug 18;8(16):2179-84
    In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI.[Pubmed: 9873509]

    METHODS AND RESULTS:
    The three chromanone derivatives, (+)-, (-)-, and (+/-)-12-Oxocalanolide A (2), were evaluated for in vitro antiviral activities against HIV and simian immunodeficiency virus (SIV).
    CONCLUSIONS:
    The compounds were determined to be inhibitors of HIV-1 reverse transcriptase (RT) and exhibited activity against a variety of viruses selected for resistance to other HIV-1 nonnucleoside RT inhibitors. They are the first reported calanolide analogues capable of inhibiting SIV.
    J Chromatogr B Biomed Sci Appl. 2000 Jun 9;742(2):267-75.
    Quantification of (+)-calanolide A, a novel and naturally occurring anti-HIV agent, by high-performance liquid chromatography in plasma from rat, dog and human.[Pubmed: 10901131]

    METHODS AND RESULTS:
    A HPLC method was validated for quantification of (+)-calanolide A (1), a novel anti-HIV agent, in rat, dog and human plasma. The synthetic intermediate (+/-)-12-Oxocalanolide A (2) was found to be a suitable internal standard. Compounds were extracted from plasma using a solid-phase C(18) cartridge and quantified over the assay range of 12.5 to 800 ng/ml. The method was utilized to determine (+)-calanolide A pharmacokinetics in rats, dogs and humans. This is the first report of a validated HPLC assay for determination of (+)-calanolide A concentrations in rat and dog plasma as well as human plasma obtained from clinical trials.
    CONCLUSIONS:
    There was no evidence of in vivo epimerization of (+)-calanolide A to its inactive epimer (+)-calanolide B (3).
    Gancaonin N

    Catalog No: CFN95066
    CAS No: 129145-52-4
    Price: $463/5mg
    Cassiaglycoside II

    Catalog No: CFN95130
    CAS No: 2241081-56-9
    Price: $368/5mg
    3,7,25-Trihydroxycucurbita-5,23-dien-19-al

    Catalog No: CFN95150
    CAS No: 85372-65-2
    Price: $318/5mg
    3-O-[5'''-O-feruloyl-beta-D-apiofuranosyl(1'''->2'')-beta-D-glucopyranosyl] rhamnocitrin

    Catalog No: CFN95154
    CAS No: 148210-00-8
    Price: $413/5mg
    Specioside B

    Catalog No: CFN95165
    CAS No: 126589-95-5
    Price: $368/5mg
    New compound 3

    Catalog No: CFN95184
    CAS No: N/A
    Price: $368/5mg
    Nardoaristolone B

    Catalog No: CFN95203
    CAS No: 1422517-82-5
    Price: $398/5mg
    Cannabisin B

    Catalog No: CFN95268
    CAS No: 144506-17-2
    Price: $413/5mg
    5,6,7,3',4',5'-Hexamethoxyflavanone

    Catalog No: CFN95376
    CAS No: 74064-17-8
    Price: $318/10mg
    3-Oxo-alpha-ilexanolic acid

    Catalog No: CFN95496
    CAS No: N/A
    Price: $413/5mg