1-Methoxyindole-3-carboxylic acid
Standard reference
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Xenobiotica. 1991 May;21(5):569-74.
In vitro O-demethylation from a heterocyclic nitrogen: a novel metabolic reaction?[Pubmed:
1949889]
METHODS AND RESULTS:
1. O-Demethylation of 1-Methoxyindole-3-carboxylic acid, in vitro, by determination of liberated formaldehyde, has been demonstrated using fortified 15,000 g rat liver supernatant fraction. 2. Results have been compared to those similarly obtained with a standard O-demethylation substrate, 4-nitroanisole, to substantiate and quantify the extent of the reaction. 3. Km values for 4-nitroanisole and methoxyindole-3-carboxylic acid were 8.9 and 6.5 mM, while Vmax values were 4.9, and 5.2 nmol HCHO produced/mg protein per min.
CONCLUSIONS:
4. The significance of the metabolic O-demethylation reaction for N-methoxyindoles as a novel metabolic pathway is discussed in terms of pharmacological activity and biological reactivity.
