1-2-Cyclohexanedione

Biochem Biophys Res Commun. 1981 Mar 16;99(1):243-51.

Inhibition of anion transport across red blood cells with 1,2-cyclohex-anedione[Reference: WebLink]

METHODS AND RESULTS:
The effects of three different α dicarbonyl reagents on SO4 equilibrium exchange across the red cell membrane have been studied. It was found that 1,2-cyclohexanedione(1-2-Cyclohexanedione ), an arginine specific reagent [1], causes inhibition of transport and a reduction of the capacity of the band 3 protein to bind the specific transport inhibitor H2DIDS. The effect on the H2DIDS binding capacity was, however, considerably smaller than the inhibition of sulfate transport indicating that the inhibition involved a modification of sites other than the H2DIDS binding site. Squaric acid and 1,3-cyclohexanedione produced no inhibition under conditions where 1,2-cyclohexanedione (1-2-Cyclohexanedione )was fully inhibitory.
CONCLUSIONS:
The results suggest that besides the lysine residues [2] involved in H2DIDS-binding guanidino groups may also play a role in anion transport across the red blood cell membrane.

J Phys Chem A. 2015 Mar 5;119(9):1464-8.

Microwave measurements of the spectra and molecular structure for the monoenolic tautomer of 1,2- cyclohexanedione.[Pubmed: 25006688]

METHODS AND RESULTS:
The microwave spectrum for the monoenolic tautomer of 1-2-Cyclohexanedione was measured in the 4-14 GHz regime using a pulsed-beam Fourier transform (PBFT), Flygare-Balle-type microwave spectrometer. The molecular structure and moments of inertia were initially calculated using Gaussian 09 using MP2 and 6-311++G** basis sets, and these calculations were used to predict the rotational constants and microwave spectra.

J Phys Chem A. 2013 Mar 28;117(12):2415-26.

Photodissociation dynamics of enolic 1,2-cyclohexanedione at 266, 248, and 193 nm: mechanism and nascent state product distribution of OH.[Pubmed: 23444923]

METHODS AND RESULTS:
The photodissociation dynamics of 1-2-Cyclohexanedione (CHD), which exists in enolic form in gas phase, is studied using pulsed laser photolysis (LP)-laser induced fluorescence (LIF) "pump-and-probe" technique at room temperature.