1-2-Cyclohexanedione
1,2-Cyclohexanedione, an arginine specific reagent , causes inhibition of transport and a reduction of the capacity of the band 3 protein to bind the specific transport inhibitor H 2DIDS.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Biochem Biophys Res Commun. 1981 Mar 16;99(1):243-51.
Inhibition of anion transport across red blood cells with 1,2-cyclohex-anedione[Reference:
WebLink]
METHODS AND RESULTS:
The effects of three different α dicarbonyl reagents on SO4 equilibrium exchange across the red cell membrane have been studied. It was found that 1,2-cyclohexanedione(1-2-Cyclohexanedione ), an arginine specific reagent [1], causes inhibition of transport and a reduction of the capacity of the band 3 protein to bind the specific transport inhibitor H2DIDS. The effect on the H2DIDS binding capacity was, however, considerably smaller than the inhibition of sulfate transport indicating that the inhibition involved a modification of sites other than the H2DIDS binding site. Squaric acid and 1,3-cyclohexanedione produced no inhibition under conditions where 1,2-cyclohexanedione (1-2-Cyclohexanedione )was fully inhibitory.
CONCLUSIONS:
The results suggest that besides the lysine residues [2] involved in H2DIDS-binding guanidino groups may also play a role in anion transport across the red blood cell membrane.
J Phys Chem A. 2015 Mar 5;119(9):1464-8.
Microwave measurements of the spectra and molecular structure for the monoenolic tautomer of 1,2- cyclohexanedione.[Pubmed:
25006688]
METHODS AND RESULTS:
The microwave spectrum for the monoenolic tautomer of 1-2-Cyclohexanedione was measured in the 4-14 GHz regime using a pulsed-beam Fourier transform (PBFT), Flygare-Balle-type microwave spectrometer. The molecular structure and moments of inertia were initially calculated using Gaussian 09 using MP2 and 6-311++G** basis sets, and these calculations were used to predict the rotational constants and microwave spectra.
J Phys Chem A. 2013 Mar 28;117(12):2415-26.
Photodissociation dynamics of enolic 1,2-cyclohexanedione at 266, 248, and 193 nm: mechanism and nascent state product distribution of OH.[Pubmed:
23444923]
METHODS AND RESULTS:
The photodissociation dynamics of 1-2-Cyclohexanedione (CHD), which exists in enolic form in gas phase, is studied using pulsed laser photolysis (LP)-laser induced fluorescence (LIF) "pump-and-probe" technique at room temperature.
