Cytotoxic

Valechlorine
Catalog No: CFN90622

Valeranone shows antileishmanial and cytotoxic activity.

Beta,beta-Dimethylacrylalkannin
Catalog No: CFN90626

Beta,beta-Dimethylacrylalkannin has radical scavenging activity, it exhibits inhibitory activities on PTP1B with IC50 values of 0.36±0.08 umol·L-1, it may be a new type of leading compounds for the treatment of diabetes. Beta,beta-Dimethylacrylalkannin has great potential as topo I inhibitors compared to other compounds and CPT-11, with 2-3uM inhibition value. Beta,beta-Dimethylacrylalkannin can be potential therapeutics against tumor cell growth because of its unique DNA damaging abilities additional to enzyme inhibition similar to those of doxorubicin.

Deacetyltaxol
Catalog No: CFN90687

10-Deacetyltaxol and cephalomannine have cytotoxicity in human glial and neuroblastoma cell-lines, the tumors of the central and peripheral nervous system are sensitive to 10-deacetyltaxol and cephalomannine and these drugs are less toxic than taxol but remain within a therapeutic range.

Angeloylgomisin H
Catalog No: CFN90710

Angeloylgomisin H shows moderate cytotoxic activities with IC50 values ranging from 100 to 200 ug/mL against MCF7, HEK293 and CAL27 cell lines. Angeloylgomisin H may present significant myocardial protective activity.

Pellitorine
Catalog No: CFN96143

Pellitorine is a potential larvicide with a specific target site and a lead molecule for the control of mosquito populations, it also shows antiprotozoal activity against Plasmodium falciparum (IC50 = 3.3 ug/mL). Pellitorine shows potent antiplatelet aggregation activity, it can suppress expression of inducible NO synthase and cyclooxygenase-2. Pellitorine also shows strong cytotoxic activities against HL60 and MCT-7 cell lines.