Cytotoxic

Cedrelone
Catalog No: CFN99368

Cedrelone exhibits antifeedant activity, it has insecticidal activity, it inhibits arval growth of P. saucia, and the molting of the milkweed bug, Oncopeltus fasciatus. Cedrelone and its derivatives exert antimicrobial activities, bromohydroxy cedrelone and Michael adduct show good antifungal activity. Cedrelone is also a very potent inducer of apoptosis, it can cause cell cycle arrest, it shows significant cytotoxicity against cancer cell lines, such as -60, SMMC-7721, A-549, MCF-7 and SW480.

3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone
Catalog No: CFN99369

5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it shows considerably activity against HIV-1 reverse transcriptase. It exhibits cytotoxic activity against P-388 cell lines, it can inhibit DNA topoisomerase IIα activity, which may be responsible for the observed cytotoxicity.

Hyptadienic acid
Catalog No: CFN99387

Hyptadienic acid exhibits moderate cytotoxicity against HepG2 cells.It also shows a marked anti-inflammatory effect, it also exhibits strong antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz(a)anthracene (DMBA) as an initiator and TPA as a promoter.

2',4'-Dihydroxy-3',6'-dimethoxychalcone
Catalog No: CFN99391

2',4'-Dihydroxy-3',6'-dimethoxychalcone has cytotoxic, anti-inflammatory activity and anti-cholinesterase activities, it has significant NO inhibitory activity.

Pimpinellin
Catalog No: CFN99402

Pimpinellin has phototoxic, it acts as antagonist of proteins with GABA receptor activity. Pimpinellin has anti- inflammatory, and cytotoxic activities. Pimpinellin also has anti-bacterial activity, it shows inhibitory activity against Mycobacterium tuberculosis strain H37Ra , with MICs of 812 uM and IC50s of 389 uM.