Sulfuretin
Catalog No: CFN97844
Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 through the Nrf2/ARE and JNK/ERK signaling pathways. Sulfuretin may have a potential role for neuroprotection, possibly through inhibition of phosphorylation of MAPK, PI3K/Akt, and GSK-3β, which leads to mitochondrial protection, NF-κB modulations and subsequent suppression of apoptosis via ROS-dependent pathwaysand, may be used as a therapeutic agent for PD; it also may have therapeutic value in preventing or delaying the progression of rheumatoid arthritis.Sulfuretin has therapeutical effect on leukemia, due to its potent apoptotic activity through the extrinsic pathway driven by a Fas-mediated caspase-8-dependent pathway.
Sweroside
Catalog No: CFN99455
Sweroside possesses wound healing, cytoprotective, skin-whitening , anti-osteoporotic
, and hepatoprotective effect. It can inhibit potent melanogenesis in melan-a cells at 300uM without cytotoxicity, also decreases tyrosinase, tyrosinase-related protein-1 (TRP-1) and TRP-2 protein production in melan a cells. It
also shows insulin-mimicking effects on the regulation of Pck1 expression.
Swertiamarin
Catalog No: CFN99818
Swertiamarin possesses anti-hyperglycemic, anti-hyperlipidemic, anti-diabetic activity and enhances β cell regeneration which causes reversal of diabetes. Swertiamarin also possesses significant wound healing, anti-inflammatory, antioxidant, hepatoprotective, peripheral and central antinociceptive properties. Swertiamarin inhibits the development of arthritis by modulating NF-κB/IκB and JAK2/STAT3 signaling, it acts as an anti-rheumatic agent.
