Hot Products

Procyanidin B2
Catalog No: CFN99558

Procyanidin B2 has vascular protective, anti-diabetic nephropathy,anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression of AP-1 pathway, and up-regulated the expression of GSTP1 via a mechanism that involves ERK and p38 MAPK activation and Nrf2 translocation. It has anti- and pro-oxidant effects on metal-mediated DNA damage by interacting with H2O2 and metal ions.

Procyanidin B3
Catalog No: CFN99559

Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity. Procyanidin B3 is an inhibitor of histone acetyltransferase, B3 enhances the action of antagonist for prostate cancer cells via inhibition of p300-dependent acetylation of androgen receptor. Procyanidin B3 prevents osteoarthritis (OA) progression and heterotopic cartilage formation, at least in a part through the suppression of iNOS, these results support the potential therapeutic benefits of B3 for treatment of human OA and heterotopic ossification.

Procyanidin B4
Catalog No: CFN91171

Procyanidin B4 reveals significant antioxidant activity.

Procyanidin C1
Catalog No: CFN99560

Procyanidin C1 has anti-inflammatory effects, can inhibit IKKb activity in vitro and reduce the LPS-induced production of ROS, thus, it exerts the anti-inflammatory effects by inhibiting ERK1/2 and IKKb activity. Procyanidin C1 could be useful as a lead compound to develop inhibitors of cancer metastasis and other diseases related to epithelial-to-mesenchymal transition (EMT). Procyanidin C1 may represent a novel and potentially therapeutically relevant compound for the treatment of cardiovascular diseases, it -induced vasorelaxation is associated with the activation of the calcium-dependent NO/cGMP pathway, involving potassium channel activation.

Progesterone
Catalog No: CFN90039

Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor. Stimulation of breast cell tumorigenesis and tumor growth accompanying Progesterone treatment is due to the Progesterone metabolite 5αP, and that breast tumorigenesis can be blocked with the 5α-reductase inhibitor, finasteride.

Progoitrin
Catalog No: CFN00508

Proline
Catalog No: CFN99612

L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.Proline accumulates in many plant species in response to environmental stress, it can act as a signaling molecule to modulate mitochondrial functions, influence cell proliferation or cell death and trigger specific gene expression, which can be essential for plant recovery from stress, the engineering of proline metabolism could lead to new opportunities to improve plant tolerance of environmental stresses.

Propyl gallate
Catalog No: CFN93164

Propyl gallate shows antioxidant,and hepatoprotective activities, it can potently inhibit diphenolase activity of tyrosinase. Propyl gallate inhibits the growth of HeLa cells via regulating intracellular GSH level,it also shows inhibitory effects on selected food-borne bacteria.

Propyl paraben
Catalog No: CFN70226

Propyl paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, drugs and cosmetics for over 50 years.

Prosapogenin A
Catalog No: CFN90440

Prosapogenin A has anti-obesity, and immunomodulating effects, it exhibits cytotoxic activity against the cancer cell line K562 in vitro.