Hot Products

Nimbolide
Catalog No: CFN91919

Nimbolide is a more potent antiproliferative and apoptosis inducing agent and offers promise as a candidate agent in multitargeted prevention and treatment of cancer; it can sensitize tumor cells to chemotherapeutic agents through interaction with IKK, leading to inhibition of NF-κB-regulated proteins. Nimbolide attenuates the lipid accumulation, oxidative stress and antioxidant in primary hepatocytes. Nimbolide also has antibacterial potential.

Nintedanib (BIBF 1120)
Catalog No: CFN60186

Niranthin
Catalog No: CFN98798

Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitive inhibitor interacting with both subunits of the enzyme. Niranthin also exhibits anti-hepatitis B virus, antiinflammatory and antiallodynic actions.

Nitidine chloride
Catalog No: CFN98109

Nitidine chloride has protective effects on rats during myocardial ischemia/reperfusion, it also exerts an anti-inflammatory property by inhibiting TNF-α, IL-1β, and IL-6 production in association with reduced NF-κB and MAPK signaling pathways in RAW 264.7 cells. It has inhibitory effects on various tumors, such as renal cancer , breast cancer.

N-Methylcalycinine
Catalog No: CFN97425

N-Methylcalycinine exhibits potent AChE inhibitory activity.

N-Methylcoclaurine
Catalog No: CFN96775

N-Methylcoclaurine shows binding affinities for the ĸ opioid receptor with the equilibrium dissociation constant (Ki) value of 0.9 ± 0.1 uM. N-methylcoclaurine also shows promising butyrylcholinesterase inhibition activities, with the IC50 value of 15.0 ± 1.4 uM.

N-Methylcorydaldine
Catalog No: CFN92335

N-Methylcorydaldine has promising anti-secretory activity.

N-Methylcytisine
Catalog No: CFN99776

N-Methylcytisine's nicotinic receptors have high affinity (KD = 50 nM)to nAChR from squid optical ganglia, N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system. (−)-N-methylcytisine and (−)-anagyrine have nematicidal activity against pine wood nematodes.

N-Methyltetrahydrocolumbamine
Catalog No: CFN95590

N-Nornuciferine
Catalog No: CFN96149

N-Nornuciferine can competitively inhibit CYP2D6 activity with Ki values of 2.34 uM.