3,3',4',5,6,7,8-heptamethoxyflavone
Catalog No: CFN95021
3,3',4',5,6,7,8-Heptamethoxyflavone(HMF) has neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging and photoprotective effects; it inhibits collagenase activity and induces type I procollagen synthesis in HDFn cells, and against nitric oxide (NO) carcinogenesis.
3',4',5,5',6,7-Hexamethoxyflavone
Catalog No: CFN70332
5,6,7,3',4',5'-Hexamethoxyflavone(HMF) has anticancer activities, it inhibits growth of triple-negative breast cancer cells via suppression of MAPK and Akt signaling pathways and arresting cell cycle. HMF may potentiate Cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel activities through both elevation of cAMP level and binding to CFTR protein pathways, HMF may be developed as a new drug in the therapy of CFTR-related diseases such as bronchiectasis and habitual constipation.
3,4,5-Tricaffeoylquinic acid
Catalog No: CFN90238
3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor 4 expression-mediated activation of the Akt, ERK and NF-ĸB pathways, it may exert an inhibitory effect against the pro-inflammatory mediator-induced skin disease. 3,4,5-Tricaffeoylquinic acid may attenuate the proteasome inhibitor-induced programmed cell death in PC12 cells by suppressing the activation of the mitochondrial pathway and the caspase-8- and Bid-dependent pathways, the effect be attributed to its inhibitory effect on the formation of reactive oxygen species and depletion of GSH.
3,4,5-Trimethoxycinnamic acid
Catalog No: CFN98182
3,4,5-Trimethoxycinnamic acid has anti-stress effect, prolonging the sleeping time in animals. 3,4,5-Trimethoxycinnamic acid may exert anti-seizure activity by acting at the GABAA/BZ receptor complex. It shows hypoxia inducible factor-2 (HIF-2) inhibitory activity with EC50 value of 60.6 uM. 3,4,5-Trimethoxycinnamic acid derivatives have a potential antinarcotic effect through acting as a 5-HT(1A) receptor agonist in mice.
