2,3,24-Trihydroxy-12-ursen-28-oic acid
2α,3α,24-Trihydroxyurs-12-en-28-oic acid, a triterpenoid phytoalexin, shows antifungal activity against the fungus mentioned. It also shows in vitro cytotoxic activity against tumor cell lines including PLC,Hep3B,HepG2,HeLa,SW480,MCF-7 and Bel7402.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Chinese Journal of Natural Medicines, 2010, 8(4):260-3.
Four Triterpenoids with Cytotoxic Activity from the Leaves of Actinidia valvata[Reference:
WebLink]
To study the chemical constituents of the leaves of Actinidia valvata Dunn.
METHODS AND RESULTS:
Several chromatographic methods were applied to isolate and purify compounds and their structures were elucidated by spectroscopic methods. Four triterpenoids including corosolic acid(1),2α,3β,24-trihydroxyurs-12-en-28-oic acid(2,3,24-Trihydroxy-12-ursen-28-oic acid
,2),2α,3α,24-trihydroxyurs-12-en-28-oic acid(3) and 2α,3α,19α,24-tetrahydroxyurs-12-en-28-oic acid(4) were isolated from Actinidia valvata Dunn.They all showed in vitro cytotoxic activity against tumor cell lines including PLC,Hep3B,HepG2,HeLa,SW480,MCF-7 and Bel7402.
CONCLUSIONS:
These 4 compounds were all obtained from the plant for the first time.
Phytochemistry, 1999, 52(4):623-9.
Triterpene phytoalexins from nectarine fruits[Reference:
WebLink]
METHODS AND RESULTS:
Seven triterpenoid phytoalexins were isolated from peel of unripe fruits of nectarine (Prunus persica cv Fantasia) wounded and inoculated with Colletotrichum musae. Two were new triterpenoids, identified as 1β,2α,3α,24-tetrahydroxyurs-12-en-28-oic acid and 1β,2α,3α,24-tetrahydroxyolean-12-en-28-oic acid. 2α,3α,24-Trihydroxyolean-12-en-28-oic acid, 2α,3α,24-trihydroxyurs-12-en-28-oic acid(2,3,24-Trihydroxy-12-ursen-28-oic acid), 2α,3β,24-trihydroxyolean-12-en-28-oic acid, 2α,3α-dihydroxyolean-12-en-28-oic acid, and 2α,3α-dihydroxyurs-12-en-28-oic acid were previously reported as constitutive natural products from other plants, but were never described as phytoalexins.
CONCLUSIONS:
All showed antifungal activity against the fungus mentioned.
