Sprengerinin C
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can strongly suppress tumor angiogenesis in human umbilical vein endothelial cells, it blocks vascular endothelial growth factor receptor 2-dependent phosphoinositide 3-kinase/Akt/mTOR/matrix metalloproteinase and p38 MAPK/matrix metalloproteinase pathways,two major pathways for tumor angiogenesis.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Eur J Pharmacol. 2013 Aug 15;714(1-3):261-73.
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis.[Pubmed:
23684542 ]
The multi-targeted therapy for liver cancer has been considered as a novel strategy to fight hepatocellular carcinoma.
METHODS AND RESULTS:
In this study, we first found that Sprengerinin C, a naturally derived compound strongly suppressed tumor angiogenesis in human umbilical vein endothelial cells. A mechanism study revealed that Sprengerinin C blocked vascular endothelial growth factor receptor 2-dependent phosphoinositide 3-kinase/Akt/mTOR/matrix metalloproteinase and p38 MAPK/matrix metalloproteinase pathways, two major pathways for tumor angiogenesis. Moreover, Sprengerinin C inhibited vascular endothelial growth factor release, a vital event for early angiogenesis response, from hypoxic HepG-2/BEL7402 cells by suppressing hypoxia-inducible factor-1α transcriptional activity. Furthermore, Sprengerinin C induced HepG-2/BEL7402 cell apoptosis by activating NADPH oxidase/reactive oxygen species-dependent caspase apoptosis pathway and suppressed HepG-2/BEL7402 cell growth through p53-mediated G2/M-phase arrest. Sprengerinin C also showed a significant anti-tumor effect in the nude mouse xenograft model of human hepatocellular carcinoma.
CONCLUSIONS:
These results provide new insights into development of potent candidate compounds for liver cancer through affecting multiple tumor progression steps of angiogenesis, apoptosis and proliferation.
Chinese Journal of Organic Chemistry,2008,8(9):1620-3.
Structural elucidation of steroidal glycosides from Ophiopogon japonicus[Reference:
WebLink]
METHODS AND RESULTS:
A new steroidal 14-hydroxy Sprengerinin C(1) was isolated from the tuber of Ophiopogon ja-ponicus(Thunb.) Ker-Gawl.,along with three known compounds,Sprengerinin C(2) ,ophiogenin-3-O-α-L-rhamnopyranosyl-(1→2) -β-D-glucopyranoside(3) and β-sitosterol-β-D-glucopyranoside(4) . Their struc-tures were established on the basis of IR,HR-MS,1D and 2D-NMR analyses,as well as by literature com-parison of spectroscopic data.
