Vulpic acid

Vulpic acid
Product Name Vulpic acid
CAS No.: 521-52-8
Catalog No.: CFN94427
Molecular Formula: C19H14O5
Molecular Weight: 322.32 g/mol
Purity: >=98%
Type of Compound: Miscellaneous
Physical Desc.: Powder
Targets: Fatty Acid Synthase
Source: From lichen metabolites.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $198/5mg
Vulpic acid has therapeutic and prophylactic potential to be antibacterial and antiplasmodial agents, it can inhibit one or more enzymes (PfFabI, PfFabG, and PfFabZ) from the plasmodial fatty acid biosynthesis (FAS-II) pathway, a potential drug target for liver stage activity.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Int J Mol Sci.2023, 24(23):17118.
  • Molecules 2022, 27(3),1047.
  • Vietnam Journal of Food Control2022, 5(3):pp.390-401.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • Herbal Formula Science2024, 32(3):203-221
  • J Nat Prod.2019, 82(4):1002-1008
  • J Med Food.2019, 22(10):1067-1077
  • J Cell Physiol.2020, 10.1002
  • Journal of Functional Foods2021, 84:104581
  • Phytomedicine Plus2024, 4(4): 100655.
  • (2R,4S)-3,4-Dihydro-4-hydroxy-2,7-dimethyl-1(2H)-naphthalenone

    Catalog No: CFN95673
    CAS No: 1932291-56-9
    Price: $318/5mg
    Pyrolone B

    Catalog No: CFN95694
    CAS No: 1014978-30-3
    Price: $368/mg
    4-(cis)-Acetyl-3,6,8-trihydroxy-3-methyldihydronaphthalenone

    Catalog No: CFN97769
    CAS No: 263368-92-9
    Price: Inquiry(manager@chemfaces.com)
    4-(trans)-Acetyl-3,6,8-trihydroxy-3-methyldihydronaphthalenone

    Catalog No: CFN97770
    CAS No: 263368-91-8
    Price: Inquiry(manager@chemfaces.com)
    Brevifolincarboxylic acid

    Catalog No: CFN93653
    CAS No: 18490-95-4
    Price: $318/20mg
    Vulpic acid

    Catalog No: CFN94427
    CAS No: 521-52-8
    Price: $198/5mg
    J Nat Prod. 2013 Jun 28;76(6):1064-70.
    Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.[Pubmed: 23806111]
    Chemicals targeting the liver stage (LS) of the malaria parasite are useful for causal prophylaxis of malaria.
    METHODS AND RESULTS:
    In this study, four lichen metabolites, evernic acid (1), Vulpic acid (2), psoromic acid (3), and (+)-usnic acid (4), were evaluated against LS parasites of Plasmodium berghei. Inhibition of P. falciparum blood stage (BS) parasites was also assessed to determine stage specificity. Compound 4 displayed the highest LS activity and stage specificity (LS IC50 value 2.3 μM, BS IC50 value 47.3 μM). The compounds 1-3 inhibited one or more enzymes (PfFabI, PfFabG, and PfFabZ) from the plasmodial fatty acid biosynthesis (FAS-II) pathway, a potential drug target for LS activity. To determine species specificity and to clarify the mechanism of reported antibacterial effects, 1-4 were also evaluated against FabI homologues and whole cells of various pathogens (S. aureus, E. coli, M. tuberculosis).
    CONCLUSIONS:
    Molecular modeling studies suggest that lichen acids act indirectly via binding to allosteric sites on the protein surface of the FAS-II enzymes. Potential toxicity of compounds was assessed in human hepatocyte and cancer cells (in vitro) as well as in a zebrafish model (in vivo). This study indicates the therapeutic and prophylactic potential of lichen metabolites as antibacterial and antiplasmodial agents.
    7,2',4'-Trihydroxy-5-methoxy-3-arylcoumarin

    Catalog No: CFN95070
    CAS No: 1092952-62-9
    Price: Inquiry(manager@chemfaces.com)
    3'-Hydroxymirificin

    Catalog No: CFN95102
    CAS No: 168035-02-7
    Price: $338/5mg
    1,7-Diphenyl-5-hydroxy-4,6-hepten-3-one

    Catalog No: CFN95171
    CAS No: 87095-77-0
    Price: $318/10mg
    Polygalasaponin XXXV

    Catalog No: CFN95176
    CAS No: 184479-28-5
    Price: $463/5mg
    Arisantetralone B

    Catalog No: CFN95211
    CAS No: 1161947-96-1
    Price: $413/5mg
    Dioscoreside E

    Catalog No: CFN95346
    CAS No: 435321-73-6
    Price: $318/5mg
    Gardoside methyl ester

    Catalog No: CFN95467
    CAS No: 93930-20-2
    Price: $318/10mg
    Maingayone

    Catalog No: CFN95479
    CAS No: 271585-66-1
    Price: $318/10mg
    New compound 21

    Catalog No: CFN95560
    CAS No: N/A
    Price: $413/5mg
    4-Keto-laurifoline

    Catalog No: CFN95594
    CAS No: N/A
    Price: $318/10mg