Vitexdoin A
Vitexdoin A is a natural product from Vitex negundo.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Cells.2022, 11(8), 1311.
Int J Mol Sci.2021, 22(16):8641.
Dermatologica Sinica2024, 42(1):p19-30.
Acta Pharmaceutica Hungarica2016, 86:35-40
Neurotox Res.2022, 40(6):1937-1947.
J Ginseng Res.2023, 47(4):572-582.
Int J Oncol.2019, 55(1):320-330
Korean Journal of Pharmacognosy.2019, 50(1):65-71
Plants (Basel).2021, 10(5):951.
Antioxidants (Basel).2022, 11(12):2496.
Related and Featured Products
J Nat Prod. 2009 Sep;72(9):1627-30.
Nitric oxide scavenging lignans from Vitex negundo seeds.[Pubmed:
19715321 ]
METHODS AND RESULTS:
A new phenyldihydronaphthalene-type lignan, Vitexdoin A (1), a new phenylnaphthalene-type lignan alkaloid, vitedoamine B (2), four new phenylnaphthalene-type lignans, vitexdoins B-E (3-6), and four known lignan derivatives (7-10) were isolated from Vitex negundo seeds. Their structures were elucidated by detailed analyses of NMR, IR, and MS data. The ability of the isolates to prevent nitric oxide (NO) production by LPS-stimulated RAW 264.7 macrophages in a concentration-dependent manner was also studied.
CONCLUSIONS:
Compounds 5, 6, and 9 were among the most potent NO production inhibitors, with IC(50) values of 0.13, 0.15, and 0.11 microM, respectively. The introduction of free hydroxy groups plays a vital role in the potency of these compounds.
