(+/-)-Vestitol
Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to be applied in the pharmaceutical and food industries. Vestitol inhibits neutrophils migration in the inflammatory process.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J Agric Food Chem. 2013 May 15;61(19):4546-50.
Anti-inflammatory and antimicrobial evaluation of neovestitol and vestitol isolated from Brazilian red propolis.[Pubmed:
23607483 ]
The objective of this study was to evaluate anti-inflammatory and antimicrobial activities of neovestitol and vestitol((+/-)-Vestitol) isolated from Brazilian red propolis (BRP).
METHODS AND RESULTS:
BRP ethanolic extract (EEP), neovestitol, and vestitol((+/-)-Vestitol) were evaluated by anti-inflammatory properties using a neutrophil migration assay. The antimicrobial activity was evaluated by minimal inhibitory and bactericidal concentrations (MIC and MBC) against Streptococcus mutans , Streptococcus sobrinus , Staphylococcus aureus , and Actinomyces naeslundii . Neovestitol, vestitol((+/-)-Vestitol), and EEP inhibited neutrophil migration at a dose of 10 mg/kg. Regarding antimicrobial activity, neovestitol showed MICs ranging from <6.25 to 25-50 μg/mL and MBCs ranging from 25-50 to 50-100 μg/mL, while vestitol((+/-)-Vestitol) showed MICs ranging from 25-50 to 50-100 μg/mL and MBCs ranging from 25-50 to 50-100 μg/mL.
CONCLUSIONS:
Both isoflavonoids neovestitol and vestitol((+/-)-Vestitol) are consistent bioactive compounds displaying anti-inflammatory and antimicrobial activities that can strongly act in a low dose and concentration and have a promising potential to be applied in the pharmaceutical and food industries.
Fine Chemicals, 2004, 21(7):525-8.
Antioxidation Activities of Natural Components from Dalbergia odorifera T.Chen[Reference:
WebLink]
The antioxidation activities of natural components extracted from Dalbergia odorifera T.Chen on lard and ascidian oil were investigated by OSI.
METHODS AND RESULTS:
Dalbergia odorifera T.Chen was extracted with 95% ethanol,and the extract was then extracted by petroleum ether,CHCl_3,EtOAc and BuOH successively.The residue of EtOAc had very good antioxidation activity.Eight components were isolated from it,i.e.,2,4-dihydroxy-5-methoxybenzophenone(Ⅰ),2′,3′,7-trihydroxy-4-methoxyisoflavone(Ⅱ),3′-methoxydaidzin(Ⅲ),4′,5,7-trihydroxy-3-methoxyflavone(Ⅳ),vestitol((+/-)-Vestitol,Ⅴ),medicarpin(Ⅵ),2-propenyl hexanoate(Ⅶ) and ethyl hexadecanoate(Ⅷ).
CONCLUSIONS:
The results showed that components Ⅰ,Ⅲ,Ⅴ and Ⅵ had antioxidation activity and components Ⅱ and Ⅳ had strong antioxidant activities both on lard and ascidian oil at 0.02% and 0.04% levels.
J Nat Prod. 2016 Apr 22;79(4):954-60.
Vestitol Isolated from Brazilian Red Propolis Inhibits Neutrophils Migration in the Inflammatory Process: Elucidation of the Mechanism of Action.[Pubmed:
26938776 ]
Vestitol((+/-)-Vestitol) is an isoflavonoid isolated from Brazilian red propolis with potential anti-inflammatory activity. This study investigated the mechanism of action of vestitol on the modulation of neutrophil migration in the inflammatory process.
METHODS AND RESULTS:
Pre-treatment with vestitol((+/-)-Vestitol) at 1, 3, or 10 mg/kg reduced LPS- or mBSA-induced neutrophil migration and the release of CXCL1/KC and CXCL2/MIP-2 in vivo. Likewise, pre-treatment with vestitol at 1, 3, or 10 μM reduced the levels of CXCL1/KC and CXCL2/MIP-2 in macrophage supernatants in vitro. Moreover, the administration of vestitol((+/-)-Vestitol) (10 mg/kg) reduced leukocyte rolling and adherence in the mesenteric microcirculation of mice. The pre-treatment with vestitol((+/-)-Vestitol) (10 mg/kg) in iNOS(-/-) mice did not block its activity concerning neutrophil migration. With regard to the activity of vestitol on neutrophils isolated from the bone marrow of mice, there was a reduction on the chemotaxis of CXCL2/MIP-2 or LTB4-induced neutrophils and on calcium influx after pre-treatment with the compound at 3 or 10 μM. There was no change in CXCR2 expression by neutrophils treated with vestitol((+/-)-Vestitol) at 10 μM.
CONCLUSIONS:
These findings demonstrate that vestitol((+/-)-Vestitol) is a promising novel anti-inflammatory agent.
