Vasicinol
Vasicinol shows a high sucrase inhibitory activity, and the IC50 values was 250 μM.vasicinol could be an useful treatment for metabolic disorders.Vasicinol and vasicinone severe antifertility effects are exhibited by vasicinol against Dysdercus skoenigii and Tribolium castaneum due to blocking of oocytes in the oviduct.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Food Chem. 2008 Jun 1;108(3):965-72.
Inhibitory effect on α-glucosidase by Adhatoda vasica Nees.[Pubmed:
26065759]
Methanolic extracts from the medicinal parts of 40 traditional Chinese herbs were tested in screening experiments for rat intestinal α-glucosidase.
METHODS AND RESULTS:
The methanolic extract from the leaves of Adhatoda vasica Nees (Acanthaceae) showed the highest sucrase inhibitory activity with sucrose as a substrate. Enzyme assay-guided fractionation of this extract afforded vasicine (1) and Vasicinol (2), and the structures of these compounds were elucidated on the basis of MS and NMR analysis. Compounds 1 and 2 showed a high sucrase inhibitory activity, and the IC50 values were 125μM and 250μM, respectively. Both 1 and 2 were shown to be reversible inhibitors of sucrase. Kinetic data revealed that compounds 1 and 2 inhibited sucrose-hydrolysing activity of rat intestinal α-glucosidase competitively with Ki values of 82μM and 183μM, respectively. This is the first report on the mammalian α-glucosidase inhibition of A. vasica and the inhibitory effect on sucrase by 1 and 2 from this herb species.
CONCLUSIONS:
These results suggest a use of the extract of A. vasica as an antidiabetic agent and show a possibility that compounds 1 and 2 could be an useful treatment for metabolic disorders.
Tetrahedron: Asymmetry, 1996,7(1):25–28.
Reversal of absolute stereochemistry of the pyrrolo[2,1-b]quinazoline alkaloids vasicine, vasicinone, vasicinol and vasicinolone[Reference:
WebLink]
METHODS AND RESULTS:
The previously assigned 3R configuration of (−)-vasicinone has been reversed and this pyrrolo[2,1-b]quinazoline-9-one has been shown to have the 3S-configuration (3) on the basis of an X-ray diffraction study of (+)-vasicinone hydrobromide. Likewise, the 3R stereochemistry assigned earlier to (−)-vasicine (peganine) (1) on the basis of an X-ray analysis of its hydrochloride has also been reversed by reinvestigation of the X-ray diffraction analysis of the hydrobromide. The absolute stereochemistry of the alkaloids (+)-Vasicinol (2) and Vasicinolone (5) which have been inter-related, should also have the 3S-configuration.
CONCLUSIONS:
A study of the 1H nmr spectroscopy of (−)-vasicine by the use of Mosher's method using MTPA [α-methoxy-α-(trifluoromethyl)phenylacetic acid] esters indicated an exception to this model for establishing the absolute configuration.
