Vasicine
Vasicine, a potential natural cholinesterase inhibitor, has been in development for treatment of Alzheimer's disease. Vasicine can regulate the inflammatory reaction, have great potentials to develop safe medications for respiratory and reproductive medicine.Vasicine is also oxytocic and abortifacient agents.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Pak J Pharm Sci. 2012 Jul;25(3):651-6.
Enzyme inhibition, antioxidant and antibacterial potential of vasicine isolated from Adhatoda vasica Nees.[Pubmed:
22713956 ]
Vasicine (1) was isolated from the ethanolic extract of Adhatoda vasica Nees (Acanthaceae) and the structure was confirmed using spectroscopic techniques.
METHODS AND RESULTS:
Acetylcholine esterase, trypsin, DPPH inhibition potential and FRAP assay were carried out using in vitro models. The results showed 38.4 ± 1.2% and 37.4 ± 1.1% activity in acetylcholine and trypsin inhibition assays respectively. The compound (1) exhibited significant DPPH inhibition activity (70.4 ± 1.3%, IC(50) = 212.3 ± 1.9 μM). A dose dependant behavior of Vasicine (1), was indicated in the FRAP assay.
CONCLUSIONS:
Antibacterial activity was checked according to agar well diffusion assay and results revealed that Vasicine (1) showed moderate activity.
PLoS One. 2015 Apr 7;10(4):e0122366.
In vitro and in vivo metabolism and inhibitory activities of vasicine, a potent acetylcholinesterase and butyrylcholinesterase inhibitor.[Pubmed:
25849329]
Vasicine (VAS), a potential natural cholinesterase inhibitor, exhibited promising anticholinesterase activity in preclinical models and has been in development for treatment of Alzheimer's disease.
METHODS AND RESULTS:
This study systematically investigated the in vitro and in vivo metabolism of Vasicine in rat using ultra performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight mass spectrometry. Results indicated that renal clearance was the major excretion pathway of Vasicine. The acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of Vasicine and its main metabolites were also evaluated.
CONCLUSIONS:
The results indicated that although most metabolites maintained potential inhibitory activity against AChE and BChE, but weaker than that of Vasicine. Vasicine undergoes metabolic inactivation process in vivo in respect to cholinesterase inhibitory activity.
