Trillenoside A
Trillenoside A displayed marked inhibitory action towards COX-2 production in macrophagocytes of the mouse abdominal cavity stimulated by LPS at 10 microg/ml.
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Chem Pharm Bull (Tokyo). 2007 Apr;55(4):679-81.
An 18-norspirostanol saponin with inhibitory action against COX-2 production from the underground part of Trillium tschonoskii.[Pubmed:
17409572 ]
METHODS AND RESULTS:
A novel 18-norspirostanol saponin (1), along with Trillenoside A (2), was obtained from the underground parts of Trillium tschonoskii MAXIM., collected in Shennongjia Forest District, China.
CONCLUSIONS:
Based on the chemical and spectroscopic evidences, their structures were determined as shown in Fig. 1. 1 and 2 displayed marked inhibitory action towards COX-2 production in macrophagocytes of the mouse abdominal cavity stimulated by LPS at 10 microg/ml.
