Trigothysoid N
Trigothysoid N may have anti-HIV activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Phytochemistry. 2013 Dec;96:360-9.
Anti-HIV active daphnane diterpenoids from Trigonostemon thyrsoideum.[Pubmed:
24210372]
Sixteen daphnane diterpenoids, trigothysoids A-P(trigothysoid A, trigothysoid B, trigothysoid C, trigothysoid D, trigothysoid E, trigothysoid F, trigothysoid G, trigothysoid H, trigothysoid I, trigothysoid J, trigothysoid K, trigothysoid L, trigothysoid M, Trigothysoid N, trigothysoid O, trigothysoid P), along with 15 known ones, were isolated from the methanol extract of the twigs and leaves of Trigonostemon thyrsoideum.
METHODS AND RESULTS:
Their structures were established by extensive spectroscopic techniques, including 2D NMR spectroscopy and mass spectrometry. The anti-HIV-1 activity of the compounds was also evaluated in vitro, and five compounds demonstrated potent anti-HIV-1 activity, with EC50 values of 0.015-0.001 nM and TI values of 1618-17,619.
