Taxuspine B
Taxuspine B is a natural product from the Japanese yew Taxus cuspidata Sieb. et Zucc.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
J Ginseng Res.2023, 47(4):593-603.
Arch Biochem Biophys.2020, 687:108384.
Sci Rep.2023, 13(1):21690.
Pharmaceutics.2021, 13(11):1839.
J Complement Integr Med.2024, jcim-2023-0177.
Journal of functional foods2018, 171-182
Molecules.2024, 29(6):1392.
Sains Malaysiana2024, 53(4):795-805
Microb Pathog.2024, 189:106609.
Pharmacognosy Magazine2018, 14(56):418-424
Related and Featured Products
Tetrahedron, 1994, 50(25):7401-7416。
Taxuspines A ~ C, new taxoids from Japanese yew Taxus cuspidata inhibiting drug transport activity of P-glycoprotein in multidrug-resistant cells[Reference:
WebLink]
METHODS AND RESULTS:
Three new taxoids, taxuspine A, Taxuspine B, taxuspine C (1 ~ 3), possessing different skeletons from usual taxane diterpenoids consisting of a 6/8/6-membered ring system have been isolated together with known taxoids (4 ~ 12) from stems of the Japanese yew Taxus cuspidata Sieb. et Zucc. and the structures elucidated on the basis of spectroscopic data. Most of the taxoids increased cellular accumulation of vincristine in multidrug-resistant tumor cells, while taxol (12) did not show such an activity. The taxoids (1 ~ 11) showed no or weak cytotoxicity and among them, 2(Taxuspine B) and 6 reduced appreciably CaCI2-induced depolymerization of microtubules.
CONCLUSIONS:
These results suggest that some taxoids may be useful for overcoming multidrug resistance in tumor cells.