Taxiresinol

Taxiresinol
Product Name Taxiresinol
CAS No.: 40951-69-7
Catalog No.: CFN97744
Molecular Formula: C19H22O6
Molecular Weight: 346.38 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Targets: TNF-α | Immunology & Inflammation related
Source: The branches of Taxus wallichiana
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release from the human basophilic cell line, KU812. Taxiresinol can protect the hepatocytes from apoptosis via an inhibition of TNF- alpha production by activated macrophages and a direct inhibition of apoptosis induced by TNF- alpha in D-GalN/LPS-treated mice.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Plants (Basel).2021, 10(2):278.
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • University of Stuttgart2021, 11682.
  • Molecules.2021, 26(18):5665.
  • University of Limpopo2016, 1777
  • US20170000760 A12016, 42740
  • Biomed Pharmacother.2020, 125:109784.
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • Processes2021, 9(1), 153;
  • Food Sci Biotechnol.2016, 25(5):1437-1442
  • Olivil 4'-O-glucoside

    Catalog No: CFN89274
    CAS No: 76880-93-8
    Price: $298/5mg
    Massoniresinol

    Catalog No: CFN97541
    CAS No: 96087-10-4
    Price: Inquiry(manager@chemfaces.com)
    Olivil monoacetate

    Catalog No: CFN97860
    CAS No: 1016974-78-9
    Price: Inquiry(manager@chemfaces.com)
    Fargesol

    Catalog No: CFN95027
    CAS No: 128855-64-1
    Price: $318/20mg
    9-O-Acetyl-fargesol

    Catalog No: CFN95031
    CAS No: 449172-61-6
    Price: $413/5mg
    5'-Methoxylariciresinol

    Catalog No: CFN96706
    CAS No: 105256-12-0
    Price: Inquiry(manager@chemfaces.com)
    Justiciresinol

    Catalog No: CFN92502
    CAS No: 136051-41-7
    Price: Inquiry(manager@chemfaces.com)
    Ciwujiatone

    Catalog No: CFN89318
    CAS No: 218901-26-9
    Price: Inquiry(manager@chemfaces.com)
    5,5'-Dimethoxylariciresinol

    Catalog No: CFN99265
    CAS No: 116498-58-9
    Price: Inquiry(manager@chemfaces.com)
    9-O-Feruloyl-5,5'-dimethoxylariciresinol

    Catalog No: CFN99700
    CAS No: 166322-14-1
    Price: Inquiry(manager@chemfaces.com)
    Bioorg Med Chem. 2003 Nov 17;11(23):4945-8.
    Absolute configuration and anticancer activity of taxiresinol and related lignans of Taxus wallichiana.[Pubmed: 14604656]

    METHODS AND RESULTS:
    Absolute configuration of Taxiresinol 1, a lignan from the heartwood of Taxus wallichiana has been determined as 8R, 8'R, and 7'R with the help of chemical correlation method and X-ray crystallography. The anticancer activity of Taxiresinol 1 and other two lignans 2, 3 were also studied.
    CONCLUSIONS:
    Taxiresinol 1 showed notable anticancer activity in the in vitro bioassays against colon, liver, ovarian and breast cancer cell lines.
    Biol Pharm Bull. 2006 Nov;29(11):2310-2.
    Antiallergic activity of aqueous extracts and constituents of Taxus yunnanensis.[Pubmed: 17077536]
    The H2O, H2O/MeOH (1:1) extracts from the wood of Taxus yunnanensis showed a remarkable inhibitory effect on induced histamine release from the human basophilic cell line, KU812.
    METHODS AND RESULTS:
    The eleven constituents purified from the wood extracts of Taxus yunnanensis were tested by an in vitro histamine release inhibition assay. Among them, secoisolarciresinol and Taxiresinol were found to show inhibitory activities.
    CONCLUSIONS:
    A new neolignan, 2-[2-hydroxy-5-(3-hydroxypropyl)-3-methoxyphenyl]-1-(4-hydroxy-3-methoxyphenyl)propane-1,3-diol, was isolated from the wood of Taxus yunnanensis.
    J Ethnopharmacol. 2003 Dec;89(2-3):265-70.
    Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L.[Pubmed: 14611890]

    METHODS AND RESULTS:
    Four taxoids (taxusin, baccatin VI, baccatin III and 1beta-hydroxybaccatin I) and five lignans (lariciresinol, Taxiresinol, 3'-demethylisolariciresinol-9'-hydroxyisopropylether, isolariciresinol and 3-demethylisolariciresinol) were isolated from the heartwood of Taxus baccata L. (Taxaceae) growing in Turkey through chromatographic techniques. In vivo anti-inflammatory and antinociceptive activity of these compounds were investigated.
    CONCLUSIONS:
    All the compounds were shown to possess significant antinociceptive activity against p-benzoquinone-induced abdominal contractions, while only lignan derivatives significantly inhibited carrageenan-induced hind paw edema in mice.
    Planta Med. 2004 Jan;70(1):29-33.
    Hepatoprotective effect of taxiresinol and (7'R)-7'-hydroxylariciresinol on D-galactosamine and lipopolysaccharide-induced liver injury in mice.[Pubmed: 14765289]
    The hepatoprotective effect of Taxiresinol ( 1) and (7' R)-7'-hydroxylariciresinol ( 2), two tetrahydrofuran-type lignans isolated from the wood of Taxus yunnanensis, were investigated on D-galactosamine ( D-GalN)/lipopolysaccharide (LPS)-induced hepatic liver injury in mice.
    METHODS AND RESULTS:
    Pre-administration of Taxiresinol or 2 at doses of 50 and 10 mg/kg ( i. p.) at 12 and 1 h before D-GalN/LPS injection significantly inhibited hepatocyte DNA fragmentation and apoptotic body formation. Pre-treatment of these two lignans further suppressed hepatic necrosis which occur at later stage of D-GalN/LPS intoxication as demonstrated by the significant and dose-dependent reduction in serum glutamic pyruvic transaminase (sGPT) and serum glutamic oxaloacetic transaminase (sGOT) at 8 h after intoxication. The elevation of serum tumor necrosis factor-alpha (TNF- alpha) level by D-GalN/LPS toxication was significantly inhibited by Taxiresinol or 2 at doses of 50 and 10 mg/kg. Moreover, both of these lignans significantly protected hepatocytes from D-GalN/TNF- alpha-induced cell death in primary cultured mouse hepatocytes.
    CONCLUSIONS:
    These results suggested that Taxiresinol and 2 had protected the hepatocytes from apoptosis via an inhibition of TNF- alpha production by activated macrophages and a direct inhibition of apoptosis induced by TNF- alpha in D-GalN/LPS-treated mice.
    Suchilactone

    Catalog No: CFN95010
    CAS No: 50816-74-5
    Price: $338/5mg
    Lucidenic acid D2

    Catalog No: CFN95020
    CAS No: 98665-16-8
    Price: $268/5mg
    Gancaonin N

    Catalog No: CFN95066
    CAS No: 129145-52-4
    Price: $463/5mg
    Suspenoidside B

    Catalog No: CFN95071
    CAS No: 2161432-08-0
    Price: $413/5mg
    (E)-6-O-(p-coumaroyl)scandoside methyl ester

    Catalog No: CFN95192
    CAS No: 83946-90-1
    Price: $218/10mg
    Deoxy euphorbia factor L1

    Catalog No: CFN95340
    CAS No: 247099-01-0
    Price: $318/10mg
    6-Methoxyfraxinellone

    Catalog No: CFN95485
    CAS No: N/A
    Price: $318/10mg
    Massonianoside D

    Catalog No: CFN95500
    CAS No: 85115-04-4
    Price: $318/10mg
    Methyl ganoderenate F

    Catalog No: CFN95573
    CAS No: N/A
    Price: $413/5mg
    Irigenin 3'-O-glucoside

    Catalog No: CFN95578
    CAS No: N/A
    Price: $318/5mg