Swertianin

Swertianin
Product Name Swertianin
CAS No.: 20882-75-1
Catalog No.: CFN93092
Molecular Formula: C14H10O6
Molecular Weight: 274.22 g/mol
Purity: >=98%
Type of Compound: Xanthones
Physical Desc.: Powder
Targets: Immunology & Inflammation related | Antifection
Source: The herbs of Gentiana bavarica
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Swertianin may be a promising antioxidant, it has potential anti-inflammatory and antinoceceptive which could be used as drug candidates against inflammation related conditions. Swertianin exhibits significant anti-proliferative activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Nat Prod Res. 2012;26(18):1682-6.
    Activity-guided isolation of antioxidant xanthones from Swertia chirayita (Roxb.) H. Karsten (Gentianaceae).[Pubmed: 21985644]

    METHODS AND RESULTS:
    An activity-guided isolation and purification process was used to identify the DPPH (l,l-diphenyl-2-picrylhydrazyl) radical-scavenging components of Swertia chirayita. A dry, whole plant of S. chirayita was extracted with different solvents and tested for its DPPH radical-scavenging activity. The acetone : water (8 : 2) extract showed the highest total phenolic content (TPC) and DPPH radical-scavenging activity, which was column chromatographed to obtain decussatin, Swertianin, bellidifolin, isobellidifolin, amarogentin, swertianolin and mangiferin as active components. Good correlation was observed between TPC and DPPH scavenging activity among the extracts.
    CONCLUSIONS:
    The unique structure of xanthones, including the catecholic moiety and the completely conjugated system, enables them to be promising antioxidants.
    Food Science & Human Wellness, 2015, 4(4):169-179.
    Antioxidants, anti-proliferative, anti-inflammatory, anti-diabetic and anti-microbial effects of isolated compounds from Swertia corymbosa (Grieb.) Wight ex C.B. Clark – An in vitro approach[Reference: WebLink]
    The present study, antioxidant, enzyme inhibitory, anti-inflammatory and antimicrobial activity of isolated compounds such as Decussatin (1), Gentiacaulein (2), Swertianin (3), 1,8-dihydroxy-2,6-dimethoxy xanthone (methylSwertianin) (4) 8-hydroxy-1,2,4,6-tetramethoxyxanthone (5) and 1,2-dihydroxy-6-methoxyxanthone-8-O-β-d-xylopyranosyl (6) were investigated using an in vitro model.
    METHODS AND RESULTS:
    Results of antioxidant studies revealed that the compound 6 possessed an efficient 2,2-diphenyl-1-picryl-hydrazyl (DPPH) (IC50 07.19±4.56μmol/mL), 2,2-azinobis (3-ethylbenzothiozoline-6-sulfonic acid) (ABTS+) (42.62±0.25mmol/L TE/g), superoxide (57.89±3.45μmol/mL), nitric oxide (18.45±1.23μmol/mL) and hydroxyl (12.13±2.76μmol/mL) radical scavenging activities, ferric reducing antioxidant power (14.76±0.10molar Fe (II)/g), metal chelating (213.85±27.18mg EDTA/g) ability. Compounds 6 and 3 exhibited significant anti-proliferative activity. Compound 6 displayed strongest antibacterial activity against Streptococcus pneumoniae and Escherichia coli with MIC value of 3.90μg/mL and 21.21±0.25 and 20.27±0.11mm zone of inhibition at 25μg/mL concentration respectively. In the membrane stabilization and protein denaturation test 3 was the most potent with an IC50 value of 12.57, 18.75μM/mL respectively.
    Biomed Res Int. 2014;2014:542385.
    Evaluation of anticonvulsant, sedative, anxiolytic, and phytochemical profile of the methanol extract from the aerial parts of Swertia corymbosa (Griseb.) wight ex C.B. Clarke.[Pubmed: 24877112]
    The objective of the present study was to evaluate the anxiolytic, antidepressant, and anticonvulsant activity of the methanolic extract of Swertia corymbosa (SCMeOH).
    METHODS AND RESULTS:
    After acute toxicity test, oral treatment with SCMeOH at doses of 125, 250, and 500 mg/kg behavioral models of open field, elevated-plus-maze, actophotometer, rotarod, pentylenetetrazole, isoniazid, and maximal electroshock induced seizure models were utilized. In open field test, SCMeOH (125, 250, and 500 mg/kg) (P < 0.01, P < 0.001) increased the number of rearings. However, the number of central motor and ambulation (P < 0.01, P < 0.001) were reduced. Likewise, the number of entries and the time spent in open arm were increased while the number of locomotion was decreased (P < 0.001) in elevated-plus-maze and actophotometer test, respectively. SCMeOH (125-500 mg/kg) protected the mice against the pentylenetetrazole and isoniazid induced convulsions; it causes significant (P < 0.01 and P < 0.001) dose dependent increase in latency of convulsion.
    CONCLUSIONS:
    Treatment with SCMeOH reduced the duration of the tonic hind limb extension induced by electroshock. Two major compounds such as gentiopicroside and Swertianin were analyzed by HPLC system.
    International Journal of Pharmacy & Pharmaceutical Sciences, 2013, 5(3):523-529.
    Evaluation of anti-inflammatory and antinoceceptive activity of xanthones from Swertia Corymbosa (Griseb.) Wight ex C.B. Clarke[Reference: WebLink]
    This study was designed to investigate analgesic and anti-inflammatory activity of the xanthones isolated from Swertia corymbosa.
    METHODS AND RESULTS:
    Aerial part of Swertia corymbosa was extracted with petroleum ether and ethyl acetate, further subjected to chromatographic separation for isolation of xanthones. Structures of isolated xanthones were elucidated by spectroscopic methods. Anti-inflammatory (carrageenan-induced paw edema in rat), analgesic action was estimated in mice using the acetic acid-induced writhing test and the hot-plate method and the acute oral toxicity study in mice. Four known xanthones namely Decussatin (1), Gentiacaulein (2) and Swertianin (3) 1, 8-dihydroxy-2, 6-dimethoxyxanthone (4) and two new xanthones 8-hydroxy-1, 2, 4, 6-tetramethoxyxanthone (5) 1, 2, dihydroxy-6-methoxyxanthone-8-O-β-D-xylopyranosyl (6) were isolated. Among the isolated xanthones, compound 3 and 6 showed stronger suppression on carrageenan-induced rat paw edema (60.28%, 71.80 %) and increase in hot plate reaction time (9.88, 11.78 sec), while reduced the number of writhing (70.60, 76.85 %) in acetic acid test.
    CONCLUSIONS:
    Based on the results of the present study, it is concluded that compound 3 and 6 had potential anti-inflammatory and antinoceceptive which could be used as drug candidates against inflammation related conditions.
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