Serratenediol
Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity, its effects being stronger than that of a representative control, oleanolic acid. Serratenediol can promote the proliferation rate,alkaline phosphate(ALP) activity and some osteogenic gene expression of osteoblasts. Serratenediol also has significant and dose-dependent growth inhibitory effects on HL-60 cells via regulating the ratio of Bax/Bcl-xL.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Journal of South-Central University for Nationalities (Natural Science Edition), 2012, 31(3):33-7.
Effects of Serratenediol on the Osteogenic Activity of Cultured Osteoblasts in vitro.[Reference:
WebLink]
METHODS AND RESULTS:
To study the effect of Serratenediol(an extract from Lycopodium obscurum L.) on the osteogenic activity of cultured osteoblasts,MTT assay、 alkaline phosphate(ALP) assay kit and real-time PCR were used to determine the proliferation rate,ALP activity and osteogenic genes(c-jun、c-fos、Osterix、ALP、Col-Ⅰ、OC) expression of osteoblasts.The results elucidated that treatment of Serratenediol for 3 days could promote the proliferation rate,the expression of c-jun and c-fos genes and first inhibit then enhance Osterix gene of osteoblasts.
CONCLUSIONS:
Serratencdiol treatment for 9 days could enhance the expression of ALP and Col-Ⅰ genes.There was no obvious effect of Serratenediol on the expression of OC.So Serratenediol could promote the proliferation rate,ALP activity and some osteogenic gene expression of osteoblasts.It is one of the effective component from Lycopodium obscurum L.for bone healing.
Cancer Lett. 2003 Jul 10;196(2):121-6.
Cancer chemopreventive activity of serratane-type triterpenoids on two-stage mouse skin carcinogenesis.[Pubmed:
12860269]
METHODS AND RESULTS:
Eleven serratane-type triterpenoids isolated from the stem bark of Picea jezoensis (Sieb. et Zucc.) Carr. var. jezoensis (Pinaceae) and the stem bark of Picea jezoensis (Sieb. et Zucc.) Carr. var. hondoensis (Mayer) Rehder (Pinaceae) and three synthetic analogs were studied for their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). 21-EpiSerratenediol, Serratenediol, diepiSerratenediol, 3 beta-hydroxyserrat-14-en-21-one, 3 alpha-methoxy-21 beta-hydroxyserrat-14-en-16-one, 3 beta-methoxyserrat-14-en-21 beta-yl acetate, 3 alpha-methoxyserrat-14-en-21 beta-yl acetate and 3 beta-methoxyserrat-14-en-21 alpha-yl acetate demonstrated strong inhibitory effects on the EBV-EA activation without showing any cytotoxicity, their effects being stronger than that of a representative control, oleanolic acid. Furthermore, 21-epiSerratenediol exhibited a remarkable inhibitory effect on skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test using 7,12-dimethylbenz[a]anthracene as an initiator and TPA as a promoter.
CONCLUSIONS:
The result of the present investigation indicated that 21-epiSerratenediol might be valuable as a potent cancer chemopreventive agent.
Food Chem Toxicol. 2012 Aug;50(8):2629-34.
Investigation of the component of Lycopodium serratum extract that inhibits proliferation and mediates apoptosis of human HL-60 leukemia cells.[Pubmed:
22613212]
METHODS AND RESULTS:
Serratenediol (SE), a known biologically active agent, was isolated from MC fraction of LSE and was able to demonstrate significant and dose-dependent growth inhibitory effects on HL-60 cells. Similar to the effects observed with the crude LSE, the Serratenediol-related effects included the formation of apoptotic bodies and fragmented DNA, as well as the accumulation of DNA in the sub-G(1) phase of the cell cycle. Analysis of the mechanism of these events indicated that Serratenediol treated cells had an increased ratio of Bax/Bcl-xL, released the cytochrome c, activated caspase-9, -3, and cleaved poly-ADP-ribose polymerase (PARP); these observations are hallmarks of apoptotic events.
CONCLUSIONS:
Thus, the results suggest that Serratenediol can induce apoptosis via regulating the ratio of Bax/Bcl-xL in HL-60 cell lines.
Org Lett. 2001 Oct 4;3(20):3215-6.
A simple enantioselective synthesis of serratenediol.[Pubmed:
11574034]
METHODS AND RESULTS:
A short synthesis of Serratenediol is described, which involves a number of powerful key steps including (1) catalytic enantioselective syntheses of the phenyl sulfone and acylsilane shown above, (2) their coupling, and (3) further stereoselective cationic cyclizations.
