26-Nor-8-oxo-alpha-onocerin
26-Nor-8-oxo-alpha-onocerin can promote the osteoblast proliferation rate, the effect is time-dependent,concentration-dependent and differentiation state-dependent.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Journal of South-Central University for Nationalities (Natural Science Edition), 2012, 257(4 Pt 2):R726-31.
Effects of 26-NO-Ono on Activity of Cultured Osteoblasts in vitro[Reference:
WebLink]
METHODS AND RESULTS:
To study the effects of 26-Nor-8-oxo-alpha-onocerin(26-NO-Ono),an extract from Lycopodium obscurum L.,on the activity of cultured osteoblasts in vitro,different concentrations(3.33,6.66,13.32,26.64μmol/L) of 26-NO-Ono were given to cultured osteblasts.
MTT assay,alkaline phosphate(ALP) kit,real-time PCR were applied to measure the proliferation rate,activity of ALP and expression of bone-related genes in treated osteoblasts.Results showed that treatment with 26-NO-Ono for 1d can promote the osteoblast proliferation rate and 3 d can enhance the ALP activity.Treatment with 26-NO-Ono for 3 d and 9 d can inhibit the expression of bone-related genes such as BSP,Col-I and OCN in osteoblasts,while treatment for 6 d can stimulate the above 3 genes.Meanwhile,treatment with 26-NO-Ono for 6 d and 9 d could inhibit the expression of OPN gene.
CONCLUSIONS:
Our results indicated that the effect of 26-NO-Ono on osteogenic activity of osteoblast is time-dependent,concentration-dependent and differentiation state-dependent.
Yao Xue Xue Bao. 2009 Aug;44(8):891-4.
Triterpenoid from Lycopodium obscurum L.[Pubmed:
20055158]
METHODS AND RESULTS:
To study the triterpenoid constituents from air-dried whole plants of Lycopodium obscurum L., the constituents were isolated by normal-phase and reverse-phase silica gel column chromatography from the EtOAc extract. Their structures were elucidated on the basis of spectral analysis. Five triterpenoids were purified and identified as 3beta, 19alpha-dihydroxy-20beta-acetate-serrat-14-en-21beta-ol (1), serratenediol (2), alpha-onocerin (3), 26-Nor-8-oxo-alpha-onocerin (4), (3beta, 8beta, 14alpha, 21alpha)-26, 27-dinoronocerane-3, 8, 14, 21-tetrol (5).
CONCLUSIONS:
Compound 1 is a new serratane-type triterpene and compound 5 is isolated from this plant for the first time.
