26-Nor-8-oxo-alpha-onocerin

26-Nor-8-oxo-alpha-onocerin
Product Name 26-Nor-8-oxo-alpha-onocerin
CAS No.: 125124-68-7
Catalog No.: CFN99363
Molecular Formula: C29H48O3
Molecular Weight: 444.7 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The herbs of Lycopodium clavatum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
26-Nor-8-oxo-alpha-onocerin can promote the osteoblast proliferation rate, the effect is time-dependent,concentration-dependent and differentiation state-dependent.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Journal of South-Central University for Nationalities (Natural Science Edition), 2012, 257(4 Pt 2):R726-31.
    Effects of 26-NO-Ono on Activity of Cultured Osteoblasts in vitro[Reference: WebLink]

    METHODS AND RESULTS:
    To study the effects of 26-Nor-8-oxo-alpha-onocerin(26-NO-Ono),an extract from Lycopodium obscurum L.,on the activity of cultured osteoblasts in vitro,different concentrations(3.33,6.66,13.32,26.64μmol/L) of 26-NO-Ono were given to cultured osteblasts. MTT assay,alkaline phosphate(ALP) kit,real-time PCR were applied to measure the proliferation rate,activity of ALP and expression of bone-related genes in treated osteoblasts.Results showed that treatment with 26-NO-Ono for 1d can promote the osteoblast proliferation rate and 3 d can enhance the ALP activity.Treatment with 26-NO-Ono for 3 d and 9 d can inhibit the expression of bone-related genes such as BSP,Col-I and OCN in osteoblasts,while treatment for 6 d can stimulate the above 3 genes.Meanwhile,treatment with 26-NO-Ono for 6 d and 9 d could inhibit the expression of OPN gene.
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