Senecionine N-oxide
Senecionine N-oxide and senecionine have hepatotoxic activity, no antifertility effects in MeOH extract-treated hamsters.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Funct Dev Morphol. 1994;4(2):89-92.
Differing embryotoxic effects of senecionine and senecionine-N-oxide on the chick embryo.[Pubmed:
7873804 ]
METHODS AND RESULTS:
The embryotoxic properties of pyrrolizidine alkaloids senecionine (water insoluble) and Senecionine N-oxide (water soluble) were examined using the CHEST method (Chick Embryotoxicity Screening Test). The beginning of the embryotoxicity range for senecionine was found to be between 3-30 micrograms; Senecionine N-oxide, on the other hand, showed no effect even with 100 micrograms dose.
CONCLUSIONS:
On the basis of the theoretical calculation, it can be expected that senecionine embryotoxicity for mammals ranges between 10-100 mg/kg maternal body weight, overlapping in this way the known adult toxicity range. The rat LD50 of most alkaloids known to be significant for human health are in the range of 34-300 mg/kg.
J Pharm Sci. 1988 May;77(5):461-3.
Identification of senecionine and senecionine N-oxide as antifertility constituents in Senecio vulgaris.[Pubmed:
3411472]
METHODS AND RESULTS:
The MeOH extract of Senecio vulgaris L., administered po to rats on Days 1-10 postcoitum, significantly decreased the number of normal fetuses per pregnant rat found at autopsy on Day 16. Additional experiments showed a similar activity for its hepatotoxic constituents senecionine and Senecionine N-oxide, suggesting that the latter two compounds were probably responsible for the effect seen with the extract.
CONCLUSIONS:
No antifertility effects were seen in MeOH extract-treated hamsters.
