Saikosaponin F
Saikosaponin F shows anti-inflammatory effect against carrageenan-induced plantar oedema in the rat.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Anti-inflammatory and hepatoprotective activity of saikosaponin f and the root extract of Bupleurum kaoi[Reference:
WebLink]
A mixture of B. kaoi saponins, containing saikosaponin a, saikosaponin d and Saikosaponin F, showed anti-inflammatory effect against carrageenan-induced plantar oedema in the rat.
METHODS AND RESULTS:
The crude saponin mixture and Saikosaponin F exhibited a dose-dependent inhibiting effect. Antihepatotoxic activity was investigated in rats intoxicated with beta-D-galactosamine. Except for Saikosaponin F, administration of the other compounds significantly reduced the sGOT and sGPT levels.
CONCLUSIONS:
Pathological changes in rat hepatocytes such as inflammatory infiltration around the portal area, focal necrosis in the liver parenchyma, and hyaline degeneration, have been improved in all drugs treated groups.
