Retusamine | CAS:6883-16-5 | Manufacturer ChemFaces

Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Front Plant Sci.2022, 12:811166.

Plant Cell,Tissue & Organ Culture2016, 127(1):115-121

Phytomedicine.2019, 65:153089

ACS Pharmacol. Transl. Sci.2022, 5,7,479-490

Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083

Acta Agriculturae Scandinavica2015, 381-383

Molecules.2023, 28(8):3414.

Antioxidants (Basel).2022, 11(1):171.

Foods.2023, 12(12):2412.

Molecular Simulation2023, 49(8):799-815.

Chem Biol Interact. 1976 Mar;12(3-4):299-324.

Hepato- and pneumotoxicity of pyrrolizidine alkaloids and derivatives in relation to molecular structure.[Pubmed: 1253333]

METHODS AND RESULTS:
The following compounds are readily converted by rat liver microsomes in vitro into dehydroheliotridine (or dehydroretronecine): 7- and 9-angelyheliotridine, 7- and 9-angelylretronecine, 7,9-dipivalylheliotridine and otosenine. 7,9-Divalerylheliotridine, the alpha- and beta-epoxides of monocrotaline, and Retusamine yield pyrrolic metabolites more slowly. The preparation and characterisation of several alkaloid derivatives are described. Chronic lung lesions were produced by most compounds which gave chronic liver lesions, although a higher dose was required in some instances.
CONCLUSIONS:
This requirement may sometimes mean that chronic lung lesions cannot be induced because of the intervention of acute or peracute deaths. Apart from this factor, structure activity requirements for pneumotoxicity are the same as for hepatotoxicity, consistent with their being both caused by the same toxic metabolites.

Product Name	Retusamine
CAS No.:	6883-16-5
Catalog No.:	CFN00410
Molecular Formula:	C₁₉H₂₅NO₇
Molecular Weight:	379.41 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Crotalaria pallida
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: