Qingdainone
Qingdainone is active in test on melanoma B, it also shows inhibitory action against Lewis lung carcinoma in mice.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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PLoS One.2018, 13(3):e0193386
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Yao Xue Xue Bao, 1985, 20(1):45-51.
Minor constituents of qing dai, a traditional Chinese medicine. I. Isolation, structural determination and synthesis of tryptanthrin and qingdainone.[Reference:
WebLink]
METHODS AND RESULTS:
The study of Qing Dai, a traditional Chinese medicine, has resulted in the isolation of eight minor constituents Ⅲ～Ⅹ(3.3×10~(-5)～,4.2×10~(-4)%) after removing of the two major constituents Ⅰ (indigotin) and Ⅱ (indirubin). Constituent Ⅲ (C_(15)H_8 N_2O_2) was found to be identical to the known compound indolo [-2,1b]-quinazoline6,12-dione (tryptanthrin). Constituent Ⅳ (C_(23)H_(13)N_3O_2) was assigned on the basis of spectrometric data to have structure Ⅳ and confirmed by condensation of Ⅲ with diacetylindoxyl.
CONCLUSIONS:
It was first found from plant origin and designated Qingdainone. Ⅲ and Ⅳ were synthesized and found to be both active in test on melanoma B_(16) and Ⅳ also showed inhibitory action against Lewis lung carcinoma in mice.Structure determination of constituents Ⅴ～Ⅹ is in progress.
