Pseurotin A
Pseurotin A has immunosuppressive activity, it inhibits immunoglobulin E(IgE) production in vitro.It shows a moderate effect against the phytopathogenic bacteria Erwinia carotovora and Pseudomonas syringae, with IC50 values of 220 and 112 microg ml(-1), respectively. Pseurotin A shows to be active against the proliferation of four different glioma cells with IC50 values of 0.51-29.3 uM, the targeting multiple metabolic enzymes might be one of the antiglioma mechanisms of pseurotin A.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Z Naturforsch C. 2008 May-Jun;63(5-6):383-8.
Cycloaspeptide A and pseurotin A from the endophytic fungus Penicillium janczewskii.[Pubmed:
18669024]
Penicillium janczewskii K. M. Zalessky was isolated as an endophytic fungus from the phloem of the Chilean gymnosperm Prumnopitys andina.
METHODS AND RESULTS:
When grown in liquid yeast extract-malt extract-glucose broth, the fungus produced two main secondary metabolites. The compounds were for the first time isolated from this species and identified by spectroscopic methods as Pseurotin A and cycloaspeptide A. This is the first report on the production of cyclic peptides by endophytic fungi from Chilean gymnosperms.
CONCLUSIONS:
Pseurotin A and cycloaspeptide A presented low cytotoxicity towards human lung fibroblasts with IC50 > or = 1000 microM.
Pseurotin A showed a moderate effect against the phytopathogenic bacteria Erwinia carotovora and Pseudomonas syringae, with IC50 values of 220 and 112 microg ml(-1), respectively.
Bioorg Med Chem Lett. 2009 Mar 1;19(5):1457-60.
Pseurotin A and its analogues as inhibitors of immunoglobulin E [correction of immunoglobuline E] production.[Pubmed:
19179074 ]
METHODS AND RESULTS:
A natural product, Pseurotin A inhibits IgE production in vitro. Wide variety of chemical modification of Pseurotin A was performed.
CONCLUSIONS:
Structure-activity relationship studies of Pseurotin Analogues elucidated that 10-deoxyPseurotin A strongly inhibits IgE production with IC(50) of 0.066 microM. An immunosuppressive activity of another natural product, synerazol was also found.
Nat Prod Res. 2017 Jun 23:1-4.
Antiglioma pseurotin A from marine Bacillus sp. FS8D regulating tumour metabolic enzymes.[Pubmed:
28641457]
METHODS AND RESULTS:
Pseurotin A was isolated from a culture of marine Bacillus sp. FS8D and showed to be active against the proliferation of four different glioma cells with IC50 values of 0.51-29.3 μM. It has been found that Pseurotin A downregulated the expression of tumour glycolytic enzymes pyruvate kinase M2 (PKM2) and lactate dehydrogenase 5 (LDH5) and upregulated the expression of pyruvate dehydrogenase beta (PDHB), adenosine triphosphate synthase beta (ATPB) and cytochrome C (Cyto-C), the important regulators for tricarboxylic acid cycle and oxidative phosphorylation.
CONCLUSIONS:
The data suggested that targeting multiple metabolic enzymes might be one of the antiglioma mechanisms of Pseurotin A.
