Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-beta-D-glucose can moderately inhibit α-amylase activity, with the IC50 value of 0.03 umol/ml.
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Acta Pharm Sin B.2015, 5(4):323-9.
Asian Journal of Chemistry2018, 30(12):2699-2703
The Korea Journal of Herbology2019, 34(2):25-32
Microchemical Journal2018, 137:168-173
African J. Agricultural Research 2017, 12(13):1164-1168
Phytother Res.2018, 32(5):923-932
Int J Mol Sci.2018, 19(9):E2601
J Ethnopharmacol.2019, 244:112074
Chin J Pharm Anal.2019, 39(7):1217-1228
Biochem Biophys Res Commun.2019, 518(4):732-738
J Ethnopharmacol. 2015 Apr 2;163:256-63.
Evaluation of hypoglycemic effects of polyphenols and extracts from Penthorum chinense.[Pubmed: 25620384
METHODS AND RESULTS:
The Penthorum chinense extract possessed anti-hyperglycemic activities as shown by the decreased serum levels of glycosylated hemoglobulin A1C (HbA1c), triglyceride(TG), total cholesterol (TC), and low density lipoprotein-cholesterol (LDL-C), as well as increased serum levels of high density lipoprotein-cholesterol (HDL-C) and insulin. Penthorum chinense extract also improved the oral glucose tolerance test (OGTT) to a certain degree. Moreover, the OSTT study showed that in diabetic rats, the extract (600mg/kg) caused a significant hypoglycemic effect with a blood glucose reduction of 42% at 60min. To identify the active constituents, three polyphenols, pinocembrin-7-O-[4″,6″-hexahydroxydiphenoyl]-β-d-glucose (1), pinocembrin-7-O-[3″-O-galloyl-4″, 6″-hexahydroxydiphenoyl]-β- d-glucose (Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-beta-D-glucose,2), and thonningianin A (3) were isolated from Penthorum chinense.
Compounds 1-3 moderately inhibited α-amylase activity, with IC50 values of 0.14, 0.03, and 0.08μmol/ml, respectively.