(+/-)-Pinocembrin | CAS:68745-38-0 | Manufacturer ChemFaces

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

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Chiral analytical method development and application to pre-clinical pharmacokinetics of pinocembrin.[Pubmed: 23212747 ]

An analytical method enabling the detection and quantification of the individual enantiomers of racemic (+/-)-Pinocembrin is required to fully characterize its pharmacokinetic disposition.
METHODS AND RESULTS:
Direct resolution of the enantiomers of pinocembrin was achieved using a novel and simple reversed-phase high-performance liquid chromatography method with electrospray ionization and detection by mass spectrometry in rat serum. A Chiralcel® AD-RH column was employed to perform baseline separation with electrospray positive-mode ionization with selected ion monitoring detection. The standard curves were linear from 0.5 to 100 μg/mL for each enantiomer. The limit of quantification was 0.5 μg/mL. The assay was applied successfully to stereoselective serum disposition of pinocembrin enantiomers in rats. Pinocembrin enantiomers were detected in serum. Both enantiomers had a serum half-life of ~15 min in rats. Similar values of volume of distribution between the enantiomers were also observed: 1.76 L/kg for S-pinocembrin and 1.79 L/kg for R-pinocembrin.
CONCLUSIONS:
Total clearance was 5.527 L//h/kg for S-pinocembrin and 5.535 L/h/kg for R-pinocembrin, and the area under the curve was 1.821 μg h/mL for S-pinocembrin and 1.876 μg h/mL for R-pinocembrin. The large volume of distribution coupled with the short serum half-life suggests extensive distribution of pinocembrin into the tissues.

J Asian Nat Prod Res. 2008 Sep-Oct;10(9-10):999-1002.

Synthesis and enantiomeric resolution of (+/-)-pinocembrin.[Pubmed: 19003622 ]

A convenient method for the synthesis and enantiomeric resolution of (+/-)-Pinocembrin has been developed. This route involves the hydrogenation of 5,7-dihydroxyflavone, the derivatization of racemic pinocembrin with chiral amine, and the separation of the diastereoisomers due to their different physical properties.

Product Name	(+/-)-Pinocembrin
CAS No.:	68745-38-0
Catalog No.:	CFN92629
Molecular Formula:	C₁₅H₁₂O₄
Molecular Weight:	256.3 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The herbs of Pinus armandii
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: