Pilocarpine Hydrochloride
Pilocarpine hydrochloride appears to be effective for dry mouth associated with Sjögren's syndrome. It has acaricidal activity.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Drug Test Anal.2018, 10(10):1579-1589
Biochem Biophys Res Commun.2021, 534:802-807.
Cell Mol Biol(Noisy-le-grand)2019, 65(7):77-83
Sci Rep.2024, 14(1):3684.
Braz J Biol.2023, 82:e266573.
Anat Rec2018, 24264
Natural Product Communications2020, doi: 10.1177.
J Ethnopharmacol.2024, 320:117426.
Antioxidants (Basel).2020, 9(2):E120
Cytotechnology2022, s10616
Related and Featured Products
Rev Bras Parasitol Vet. 2016 Jun 7;25(2):248-53.
In vitro effects of Pilocarpus microphyllus extracts and pilocarpine hydrochloride on Rhipicephalus (Boophilus) microplus.[Pubmed:
27334829 ]
The aim of this study was to assess the activity of aqueous (AE) and ethanolic extracts (EE) and Pilocarpine Hydrochloride, which were extracted and isolated from Pilocarpus microphyllus (Jaborandi), respectively, on Rhipicephalus (Boophilus) microplus.
METHODS AND RESULTS:
High performance liquid chromatography (HPLC) was performed to quantify these compounds. Larval packet and adult immersion tests were conducted with different concentrations. Five AE and EE concentrations, ranging from 6.2 to 100.0 mg mL-1, and six concentrations of Pilocarpine Hydrochloride, ranging from 0.7 to 24.0 mg mL-1, were tested. The lethal concentration (LC50) of each extract for larvae and engorged females was calculated through Probit analysis. The concentration of Pilocarpine Hydrochloride obtained from the EE and the AE was 1.3 and 0.3% (m/m), respectively. Pilocarpine Hydrochloride presented the highest acaricidal activity on larvae (LC50 2.6 mg mL-1) and engorged females (LC50 11.8 mg mL-1) of R.(B.) microplus, followed by the EE which presented LC50 of 56.4 and 15.9 mg mL-1, for larvae and engorged females, respectively.
CONCLUSIONS:
Such results indicate that Pilocarpine Hydrochloride has acaricidal activity, and may be the primary compound responsible for this activity by P. microphyllus EE.
Journal of Japanese Society of Oral Medicine,2009,15(1):1-8.
Effect of Pilocarpine Hydrochloride Against Dry Mouth Associated with Sjogren's Syndrome.[Reference:
WebLink]
METHODS AND RESULTS:
To evaluate the effect of Pilocarpine Hydrochloride for the treatment of dry mouth in patients with Sjögren's syndrome, 37 patients received 5 mg of Pilocarpine Hydrochloride three times daily, once after each meal, for 12 weeks. The increase in the saliva secretional capacity, the subjective and objective assessment of mouth dryness, and the subjective assessment of mouth dryness using a visual analogue scale;(VAS) were evaluated in this study. An improvement in all the subjects was observed beginning 4 weeks after the administration of Pilocarpine Hydrochloride. Twelve patients stopped taking pilocarpine because of adverse effects, mainly excessive sweating and nausea. However, no severe adverse effects occurred among the patients who continued treatment.
CONCLUSIONS:
Thus, Pilocarpine Hydrochloride appears to be effective for dry mouth associated with Sjögren's syndrome.
