Phoyunnanin C
Phoyunnanin C shows cytotoxic activity. It also shows moderate activity against the Herpes simplex virus.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Nat Prod Commun. 2014 Jun;9(6):825-7.
Chemical constituents of Dendrobium venustum and their antimalarial and anti-herpetic properties.[Pubmed:
25115090 ]
METHODS AND RESULTS:
A MeOH extract from the whole plant Dendrobium venustum exhibited significant antimalarial and anti-herpetic activities. Bioassay-guided isolation of the plant extract resulted in the isolation of seven known phenolic compounds. Densiflorol B (3) and phoyunnanin E (6) showed the strongest antimalarial activity and a high selectivity index, whereas gigantol (2), batatasin III (5) and Phoyunnanin C (7) exhibited moderate activity. Compounds 2 and 5 also showed weak activity against the Herpes simplex virus.
CONCLUSIONS:
This study is the first report on the chemical and biological activities of D. venustum.
J Asian Nat Prod Res. 2013;15(12):1256-64.
Inhibitory activities on nitric oxide production of stilbenoids from Pholidota yunnanensis.[Pubmed:
24205813]
METHODS AND RESULTS:
Three new stilbenoids, 1-(4'-hydroxybenzyl)-imbricatin, (E)-4'-hydroxy-2',3,3',5-tetramethoxystilbene, and (E)-3,4'-dihydroxy-2,6-bis(4-hydroxybenzyl)-2',3',5-trimethoxystilbene, together with 15 known stilbene derivatives, were isolated from Pholidota yunnanensis. Their structures were elucidated by spectroscopic methods and by comparison of their NMR data with those of related compounds. Furthermore, the inhibitory activities on nitric oxide (NO) production of the isolated compounds were examined in murine macrophages (RAW 264.7) activated by lipopolysaccharide. The cytotoxicity of 18 compounds was determined by the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay.
CONCLUSIONS:
Among the tested compounds, eight stilbenoids, including three dihydrophenanthrenes, three stilbenes, and one bibenzyl derivative showed inhibitory effects on NO production without cytotoxicity with IC₅₀ values ranging from 4.07 to 7.77 μM, as compared to MG-132, which was used as a positive control (IC₅₀ of 0.10 μM). One dihydrophenanthrene, Phoyunnanin C, showed cytotoxic effects at the test concentrations.
